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Synthesis and antidiabetic activity of 3,6,7-trisubstituted-2-(1H-imidazol- 2-ylsulfanyl)quinoxalines and quinoxalin-2-yl isothioureas
Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)- quinoxalines 2a-1 and 2-(quinoxalin-2-yl)-isothioureas 3a-1 were prepared. All the test compounds 2a-1 and 3a-1 were screened in vitro, in a RIN5F cell-based assay for glucose-dependent insulinotropic activity. A significant concentration and glucose-dependent insulin secretion effect was seen with compounds 2a-1 and the insulinotropic activity of compound 21 was found to be identical to that of the standard compound (6,7-dichloro-2-trifluromethyl-3-(5-methyl-1,3,4- thiadiazo-2-ylsulfanyl)-quinoxaline (1)).
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1012 | ChemSpider