Discovery of 1448-87-9

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Amination of chloro-substituted heteroarenes with adamantane-containing amines

Amination of 3,6-dichloropyridazine, chloropyrazine, 2,3and 2,6-dichloropyrazines, 2-chloroquinoxaline, 1-chloroand 1,3-dichloroisoquinolines with various adamantane-containing amines characterized by different steric hindrances at the amino group was studied. The yields of the amination products depended on the structure of starting compounds. In the reactions of all the dichloroheteroarenes, selective substitution of only one chlorine atom took place, with the best yields being observed for 2,6-dichloropyrazine. In the reaction of 1,3-dichloroisoquinoline, the chlorine atom at position 1 was selectively substituted in up to 90% yield.

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Awesome and Easy Science Experiments about 32998-25-7

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Novel multi-component synthesis of 1,4-disubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed coupling reaction/hetero-annulation in water

1,4-Disubstituted pyrrolo[1,2-a]quinoxalines were prepared through the one-pot multi-component reactions of 3-substituted-2-chloroquinoxalines, propargyl alcohol, and secondary amines, catalyzed by Pd/Cu, in the presence of K2CO3and sodium dodecyl sulfate (SDS) in water. This process provided a facile, eco-friendly, and highly efficient method for the synthesis of new pyrrolo[1,2-a]quinoxalines in water with good yields.

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Synthetic Route of 18514-76-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.18514-76-6, Name is 5-Nitroquinoxaline, molecular formula is C8H5N3O2. In a article£¬once mentioned of 18514-76-6

IrIII-Catalyzed One-Pot Cascade Synthesis of Pentacyclic-Fused Carbazoles from Indoles and Diazoes

A highly efficient IrIII-catalyzed cascade cyclization of indoles and diazoes giving access to unique pentacyclic-fused carbazoles has been developed. This novel strategy expanded the application scope of coupling partners to take diazo compounds as a C2 source, and two new cycles, three new C?C and one new C?N bonds were formed in one-pot.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N872 | ChemSpider

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Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists

To generate novel human Orexin-2 Receptor (OX2R) antagonists, a spiropiperidine based scaffold was designed and a SAR study was carried out. Compound 4f possessed the highest OX2R antagonistic activity with an IC 50 value of 3 nM with 450-fold selectivity against Orexin-1 Receptor (OX1R).

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NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1785 | ChemSpider

More research is needed about 2,3-Dichloroquinoxaline

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A kind of 2-hydrazone-thiazolo [4,5-b] quinoxaline compound and its preparation and use (by machine translation)

The invention relates to 2-hydrazone-thiazolo[4,5-b]quinoxaline compounds which are characterized in that the compounds have a general formula represented as the following, wherein R is as the following. The 2-hydrazone-thiazolo[4,5-b]quinoxaline compounds provided by the invention can be used as potential antibacterial and antitumor medicines. The invention also discloses a preparation method thereof.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1184 | ChemSpider

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Fused Tetracyclic quinoxalines from reactions of o-phenylenediamines in polyphosphoric acid

The condensation of 2,3-diaminobenzoic acid and the 5-chloro derivative with o-hydroxyphenylglyoxylic acid, isatin and benzothiophen-2,3-dione in polyphosphoric acid leads to the appropriate tetracycles. Isomeric products are formed from these unsymmetrical diamines, and methods of assigning particular structures are described.

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Electric Literature of 1448-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Review£¬once mentioned of 1448-87-9

Transition metals in organic synthesis: Highlights for the year 2000

A review with 1811 references about transition metal catalyzed or mediated reactions and functional group preparations is presented.

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Quinoxaline | C8H6N689 | ChemSpider

Awesome and Easy Science Experiments about 6-Methylquinoxaline

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Regiospecific benzoylation of electron-deficient n -heterocycles with methylbenzenes via a minisci-type reaction

A regioselective cross-dehydrogenative coupling between electron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbenzenes leading to regiospecific C-aroylation has been accomplished using AlCl3 as the catalyst in the presence of oxidant TBHP. This protocol is a practical alternative to the classical Minisci reaction.

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Quinoxaline | C8H6N16 | ChemSpider

Simple exploration of Quinoxaline-5-carboxylic acid

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Method for preparing heterocyclic-carboxylic acids

The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous suspension of a 5- or 6-hydroxymethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N768 | ChemSpider