Archives for Chemistry Experiments of 2-Chloroquinoxaline

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: quinoxaline, you can also check out more blogs about1448-87-9

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Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists

To generate novel human Orexin-2 Receptor (OX2R) antagonists, a spiropiperidine based scaffold was designed and a SAR study was carried out. Compound 4f possessed the highest OX2R antagonistic activity with an IC 50 value of 3 nM with 450-fold selectivity against Orexin-1 Receptor (OX1R).

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N586 | ChemSpider