Day: March 8, 2021

Application of 63810-80-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 63810-80-0, Name is 2,3-Dichloro-6,7-dimethylquinoxaline, molecular formula is C10H8Cl2N2. In a Article£¬once mentioned of 63810-80-0

FeCl3 catalysed 7-membered ring formation in a single pot: A new route to indole-fused oxepines/azepines and their cytotoxic activity

Various oxepine and azepine fused N-heterocyclic derivatives were synthesized using a new and one-pot reaction of 2,3-dichloro quinoxaline/pyrazine with 2-(1H-indol-2-yl)phenol/aniline in the presence of 25 mol% FeCl3. The reaction proceeded via C-C bond followed by C-X (X = O or N) bond formation to construct the central 7-membered ring, affording the desired products in good yields. The structure assignment was confirmed by the single crystal X-ray analysis of a synthesized oxepine fused N-heterocycle derivative. Most of the synthesized compounds were found to be promising when tested for their anti-proliferative properties against cervical and breast cancer cell lines.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1834 | ChemSpider

Reference of 6924-66-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 6924-66-9, Quinoxaline-5-carboxylic acid, introducing its new discovery.

AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS

The present invention relates to amido-substituted cyclohexane compounds of general formula (I) : in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N769 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 2,3-Dichloroquinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide biological properties and diverse therapeutic applications in medicinal research. They are complementary in shapes and charges to numerous biomolecules they interact with, thereby resulting in increased binding affinity. The pharmacokinetic properties of drugs bearing quinoxaline cores have shown them to be relatively easy to administer either as intramuscular solutions, oral capsules or rectal suppositories. This work deals with recent advances in the synthesis and pharmacological diversities of quinoxaline motifs which might pave ways for novel drugs development.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1243 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 2213-63-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

ANTIMICROBIAL AGENTS

The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of X1 to X8 are N and the remaining of X1 to X8 are CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1205 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 32601-86-8, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 32601-86-8, Name is 2-Chloro-3-methylquinoxaline, molecular formula is C9H7ClN2

Static and Dynamic Properties of Quinoxalines in the Phosphorescent Triplet State from Optically Detected Magnetic Resonance

The static and dynamic properties of the phosphorescent triplet states of quinoxaline and 2,3-disubstituted derivatives in hexane have been studied at 1.4 K using the methods of optically detected magnetic resonance.In addition, the absorption and phosphorescence excitation spectra have also been measured to attain the information about the low lying excited states.A systematic comparison has been made for the purpose of examining the effect of substitution.A significant enhancement of the pumping rates for the y spin sublevel observed in the chlorine-substituted derivatives is concluded to be due to the additional indirect process of intersystem crossing which occurs from S1 of n,?* to T1 passing through the intermediate triplet state of ?,?*.A detailed discussion on the observed phosphorescence spectra originating from the three sublevels has achieved a satisfactory success in understanding the mechanisms responsible for the radiative decay processes.It is concluded that the mechanisms due to vibronic coupling with closely lying n,?* triplet states are of little importance in the systems studied here.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1048 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of Quinoxalin-6-ylmethanol, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 488834-75-9

Method for preparing heterocyclic-carboxylic acids

The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous suspension of a 5- or 6-hydroxymethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N242 | ChemSpider

Synthetic Route of 477776-17-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 477776-17-3, 6-(Chloromethyl)quinoxaline, introducing its new discovery.

Method for preparing heterocyclic-carboxylic acids

The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous suspension of a 5- or 6-hydroxymethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1061 | ChemSpider

Related Products of 15804-19-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2. In a Article£¬once mentioned of 15804-19-0

Design, synthesis, biological evaluation and molecular docking study on peptidomimetic analogues of XK469

XK469 is identified as a potent quinoxaline antineoplastic agent based on its significant clinical efficacy. It probably exerts its activity via DNA topoisomerase II (topo II) inhibition. To obtain more effective antineoplastic agents, a spectrum of peptidomimetic-type quinoxaline analogues of XK469 was herein designed, synthesized, and evaluated. Few compounds (e.g. 13a and 13b) exhibited obvious cytotoxicity indicated by in?vitro anti-proliferative assay. SAR investigation revealed that introducing of hydrophobic tert-butylamine or dodecylamine moiety at the 3-position of quinoxaline core is favorable for achieving a better anti-proliferative potency, while peptidomimetic derivatives only yielded moderate cytotoxicity. Compounds with improved anti-proliferative activities also demonstrated decent anti-metastatic potencies comparable with that of doxorubicin (Doxo) based on in?vivo mouse model study. The topo II-mediated kinetoplast DNA (kDNA) decatenation assay as well as molecular docking studies implicated that these compounds tend to be potent topo II inhibitors. Overall, compounds 13a and 13b, 13b in particular, standed out from various assessments and might be promising candidates for further chemical optimization.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N415 | ChemSpider

Synthetic Route of 6639-87-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2. In a article£¬once mentioned of 6639-87-8

Aqueous hydrofluoric acid catalyzed facile synthesis of 2,3,6-substituted quinoxalines

A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines in excellent yield is developed from theta-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N944 | ChemSpider

Application of 887590-25-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 887590-25-2, tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate, introducing its new discovery.

Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11beta-hydroxysteroid-dehydrogenase type 1

A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11beta-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11beta-HSD1 with an appropriate ADME profile and ex vivo activity in target tissues.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1878 | ChemSpider