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One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions
A series of 11-aryl-8,11-dihydrofuro[3′,4′:5,6]pyrido[3,2-f]quinoxalin-10(7H)-one derivatives were obtained via a one-pot and three-component reaction of aromatic aldehydes, 6-aminoquinoxaline and tetronic acid in EtOH. The structure of 11-(4-nitrophenyl)-8,11-dihydrofuro[3′,4′:5,6]pyrido[3,2-f]quinoxalin-10(7H)-one (4g) was confirmed by X-ray diffraction analysis. This procedure had the advantages of operation simplicity, catalyst-free and without isolating intermediates, and provided a good method for the synthesis of fused tetracyclic heterocycles containing furan, pyridine and quinoxaline moieties at the same time.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: Quinoxalin-6-amine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6298-37-9
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N101 | ChemSpider