Day: March 26, 2021

Related Products of 2213-63-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article£¬once mentioned of 2213-63-0

Design, synthesis, biological evaluation and molecular docking study on peptidomimetic analogues of XK469

XK469 is identified as a potent quinoxaline antineoplastic agent based on its significant clinical efficacy. It probably exerts its activity via DNA topoisomerase II (topo II) inhibition. To obtain more effective antineoplastic agents, a spectrum of peptidomimetic-type quinoxaline analogues of XK469 was herein designed, synthesized, and evaluated. Few compounds (e.g. 13a and 13b) exhibited obvious cytotoxicity indicated by in?vitro anti-proliferative assay. SAR investigation revealed that introducing of hydrophobic tert-butylamine or dodecylamine moiety at the 3-position of quinoxaline core is favorable for achieving a better anti-proliferative potency, while peptidomimetic derivatives only yielded moderate cytotoxicity. Compounds with improved anti-proliferative activities also demonstrated decent anti-metastatic potencies comparable with that of doxorubicin (Doxo) based on in?vivo mouse model study. The topo II-mediated kinetoplast DNA (kDNA) decatenation assay as well as molecular docking studies implicated that these compounds tend to be potent topo II inhibitors. Overall, compounds 13a and 13b, 13b in particular, standed out from various assessments and might be promising candidates for further chemical optimization.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1603 | ChemSpider

Application of 32998-25-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 32998-25-7, 2-Chloro-3-methoxyquinoxaline, introducing its new discovery.

TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS

The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 32998-25-7. In my other articles, you can also check out more blogs about 32998-25-7

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1116 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 49679-45-0, name is Ethyl 3-chloroquinoxaline-2-carboxylate, introducing its new discovery. Safety of Ethyl 3-chloroquinoxaline-2-carboxylate

Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2- [aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

Thirty-three quinoxalines bearing an aminobenxoyl or aminobenzoylglutammate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6. Among the series examined one compound (29) which was the most active also exhibited both in vitro anti-HIV protection and antifungal activity while in other two (31.37) the antifungal activity was prevailing.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1900 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 2-Chloro-7-nitroquinoxaline, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 55686-94-7, name is 2-Chloro-7-nitroquinoxaline. In an article£¬Which mentioned a new discovery about 55686-94-7

Multi-gram preparation of 7-nitroquinoxalin-2-amine

Methodologies to obtain quinoxaline compounds regioselectively are rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives are desirable to explore the entire potential of these scaffolds for academic and/or commercial application. A facile and multi-gram methodology is described to obtain compound 7-nitroquinoxalin-2-amine using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatography.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1734 | ChemSpider

Electric Literature of 1448-87-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

Synthesis of 2-(4-nitrophenoxy)quinoxaline and its reactions with hydroxide ion in micellar systems

The synthesis of 2-(4-nitrophenoxy)quinoxaline (3) is described. The reaction of (3) with hydroxide ion was studied in the presence and absence of micellar systems. Cationic micelles of cetyltrimethylammonium chloride and bromide (CTACl and CTABr) and tetradecyltrimethylammonium chloride and bromide (MTACl and MTABr) speed the reaction of (3) with hydroxide ion. The second-order rate constants at the micellar pseudophase are smaller than the second-order rate constant in water.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 1448-87-9. In my other articles, you can also check out more blogs about 1448-87-9

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N563 | ChemSpider

2213-63-0, Name is 2,3-Dichloroquinoxaline, belongs to quinoxaline compound, is a common compound. Formula: C8H4Cl2N2In an article, once mentioned the new application about 2213-63-0.

New osmium cluster compounds containing the heterocyclic ligand 2,3-bis-(diphenylphosphino)quinoxaline (dppq): Ligand isomerization and crystal structures of dppq, the isomeric clusters Os3(CO)10(dppq), and HOs3(CO)9[mu-2,3-PhP(eta1-C 6H4)(Ph2P)quinoxaline]

Treatment of the labile cluster 1,2-Os3(CO)10(MeCN) 2 (1) with the diphosphine ligand 2,3-bis(diphenylphosphino) quinoxaline (dppq) at room temperature affords 1,2-Os3(CO) 10(dppq) (2b) as the kinetic product of ligand substitution in 84% yield. 2b isomerizes to the thermodynamically more stable dppq-chelated cluster 1,1-Os3(CO)10(dppq) (2c) as the sole observable product under CO at temperatures below 358 K. The kinetics for the conversion of 2b ? 2c have been investigated by NMR spectroscopy in CDCl3 over the temperature range 323-353 K, and the reaction was found to exhibit a rate law that is first order in 2b. The calculated activation parameters [DeltaH? = 25.4(4) kcal/mol; DeltaS? = -3(1) eu] support an intramolecular isomerization scenario, one that involves the migration of phosphine and CO groups about the cluster polyhedron. The disposition of the dppq ligand in the isomeric Os3(CO) 10(dppq) clusters has been established by X-ray crystallography and 31P NMR spectroscopy. Photolysis of 2c at 366 nm leads to CO loss and ortho metalation of one of the aryl groups on the Ph2P moiety to furnish the hydride cluster HOs3(CO)9[mu- PhP(eta1-C6H4)(Ph2P)quinoxaline] (3). The isomerization behavior exhibited by 2b follows that of related diphosphine-substituted Os3 clusters prepared by us.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1361 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C8H5N3O2. Introducing a new discovery about 18514-76-6, Name is 5-Nitroquinoxaline

Oxidative N-Heterocyclic Carbene Catalyzed Dearomatization of Indoles to Spirocyclic Indolenines with a Quaternary Carbon Stereocenter

An efficient method for the asymmetric intramolecular dearomatization of indoles by using oxidative N-heterocyclic carbene catalysis is demonstrated. Valuable optically active spirocyclic indolenines bearing an all-carbon quaternary stereocenter are obtained in excellent yields and with excellent enantioselectivity. The starting indoles are readily prepared and the reactions proceed through an intramolecular indole 3-acylation with an in situ generated acyl azolium intermediate to form a spirocyclic ketone moiety.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C8H5N3O2, you can also check out more blogs about18514-76-6

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N833 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C8H7N3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 6298-37-9, name is Quinoxalin-6-amine. In an article£¬Which mentioned a new discovery about 6298-37-9

Redox-active poly(6-(1H-pyrrol-1-yl)quinoxaline) as a novel organic anode material for aqueous hybrid flow batteries

To develop efficient electrochemical energy storage systems for large-scale use of renewable energy, a novel quinoxaline-bearing redox-active conjugated polymer (poly(6-(1H-pyrrol-1-yl)quinoxaline), PPyQX) has been synthesized via a facile bromine oxidation polymerization approach and employed as electro-active anode material for aqueous hybrid flow batteries. The PPyQX displays a quasi-reversible redox reaction at ?0.79 V vs the standard hydrogen electrode (SHE) with good stability in aqueous alkaline electrolytes. An aqueous hybrid flow battery is fabricated using the PPyQX as the anode material and K4Fe(CN)6 as the catholyte, respectively, which displays an open circuit potential of 1.15 V at 50% state of charge (SOC) and a discharge capacity of 67.1 mAh g?1 at the current density of 1 A g?1. The maximum power density reaches 2.7 and 1.5 W g?1 at 100% and 50% SOC, respectively. After 1000 charge-discharge cycles, ca. 74.8% of initial discharge capacity is retained, projecting an average capacity retention rate of ~99.975% per cycle. The coulombic efficiency is near to 93.8% and the round-trip energy efficiency is kept around 80.5%.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N100 | ChemSpider

Application of 15804-19-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 15804-19-0, Quinoxaline-2,3(1H,4H)-dione, introducing its new discovery.

ZK200775: A phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

Stroke and head trauma are worldwide public health problems and leading causes of death and disability in humans, yet, no adequate neuroprotective treatment is available for therapy. Glutamate antagonists are considered major drug candidates for neuroprotection in stroke and trauma. However, N- methyl-D-aspartate antagonists failed clinical trials because of unacceptable side effects and short therapeutic time window. alpha-Amino-3-hydroxy-5-methyl- 4-isoxazolepropionate (AMPA) antagonists derived from the quinoxalinedione scaffold cannot be used in humans because of their insolubility and resulting renal toxicity. Therefore, achieving water solubility of quinoxalinediones without loss of selectivity and potency profiles becomes a major challenge for medicinal chemistry. One of the major tenets in the chemistry of glutamate antagonists is that the incorporation of phosphonate into the glutamate framework results in preferential N-methyl-D-aspartate antagonism. Therefore, synthesis of phosphonate derivatives of quinoxalinediones was not pursued because of a predicted loss of their selectivity toward AMPA. Here, we report that introduction of a methylphosphonate group into the quinoxalinedione skeleton leaves potency as AMPA antagonists and selectivity for the AMPA receptor unchanged and dramatically improves solubility. One such novel phosphonate quinoxalinedione derivative and competitive AMPA antagonist ZK200775 exhibited a surprisingly long therapeutic time window of >4 h after permanent occlusion of the middle cerebral artery in rats and was devoid of renal toxicity. Furthermore, delayed treatment with ZK200775 commencing 2 h after onset of reperfusion in transient middle cerebral artery occlusion resulted in a dramatic reduction of the infarct size. ZK200775 alleviated also both cortical and hippocampal damage induced by head trauma in the rat. These observations suggest that phosphonate quinoxalinedione- based AMPA antagonists may offer new prospects for treatment of stroke and trauma in humans.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N409 | ChemSpider

Electric Literature of 17056-99-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 17056-99-4, Name is Quinoxalin-5-ol,introducing its new discovery.

Phototransformations of 6-X-5-nitroquinoxalines

Photophysical properties and photochemical activity of 6-X-5- nitroquinoxalines with electron-donor substituents (X = H, CH3, Cl, OC2H5, NH2) ortho to the nitro group were studied. The quantum yield of the formation of 5-hydroxyquinoxaline from the corresponding nitro derivative depends on the nature of the substituent and irradiation conditions. Phototransformations can go through nitro-nitrite rearrangement with the participation of two alternative T(npi*) levels, depending on the size and electronic effects of the substituent. The latter factor is largely determined by the population on excitation of different charge-transfer states involving the nitro group.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N115 | ChemSpider