Related Products of 10500-57-9, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 10500-57-9, Name is 5,6,7,8-Tetrahydroquinoline, SMILES is C1=CC=NC2=C1CCCC2, belongs to quinoxaline compound. In a article, author is Melis, Diana R., introduce new discover of the category.
Subcellular Localisation of a Quinoline-Containing Fluorescent Cyclometallated Ir-III Complex in Plasmodium falciparum
A fluorescent analogue of a previously synthesised N,N-chelated Ir-III complex was prepared by coordination of the organic ligand to an extrinsic bis(2-phenylpyridine)iridium(III) fluorophore. This cyclometallated Ir-III complex in itself displays good, micromolar activity against the chloroquine-sensitive NF54 strain of Plasmodium falciparum. Live-cell confocal microscopy found negligible localisation of the fluorescent complex within the digestive vacuole of the parasite. This eliminated the haem detoxification pathway as a potential mechanism of action. Similarly, no localisation of the complex within the parasitic nucleus was found, thus suggesting that this complex probably does not interfere with the DNA replication process. A substantial saturation of fluorescence from the complex was found near phospholipid structures such as the plasma and nuclear membranes but not in neutral lipid bodies. This indicates that an association with these membranes, or organelles such as the endoplasmic reticulum or branched mitochondrion, could be essential to the efficacies of these types of antimalarial compounds.
Related Products of 10500-57-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 10500-57-9 is helpful to your research.
Reference:
Quinoline – Wikipedia,
,Quinoline | C9H7N – PubChem