Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Zhou, Jiadi, once mentioned the application of 36556-06-6, Recommanded Product: 36556-06-6, Name is 5,6,7,8-Tetrahydroisoquinoline, molecular formula is C9H11N, molecular weight is 133.19, MDL number is MFCD00012168, category is quinoxaline. Now introduce a scientific discovery about this category.
delta-Regioselective heteroarylation of free alcohols through 1,5-hydrogen-atom transfer
An efficient silver-catalyzed d-regioselective C(sp(3))-H heteroarylation of free alcohols has been developed. Various alcohols reacted with quinolines, isoquinoline, pyridines, pyrimidine, phthalazine, 4-hydroxyquinazoline, acridine, quinoxaline and pyrazine to give the corresponding C(sp(2))-H alkylation products in 31-89% yields. Notably, all types (1 degrees, 2 degrees, and 3 degrees) of d-C(sp(3))-H bonds in the alcohols could be regioselectively activated. This protocol provides a platform to access divergent functionalizations of alcohols and heteroaryls by forming the challenging d-selective C(sp(3))-C(sp(2)) bond.
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Reference:
Quinoline – Wikipedia,
,Quinoline | C9H7N – PubChem