In homogeneous catalysis, catalysts are in the same phase as the reactants. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 86-99-7, Name is 7-Chloroquinolin-4-ol, molecular formula is C9H6ClNO, belongs to quinoxaline compound, is a common compound. In a patnet, author is Akbari, Mosayeb, once mentioned the new application about 86-99-7, Name: 7-Chloroquinolin-4-ol.
Efficient synthesis of novel 2-(2-chloroquinolin-3-yl)imidazo[1,2-a]pyridin-3-amine derivatives
An efficient method is applied for the synthesis of novel 2-(2-chloroquinolin-3-yl)-N-alkylimidazo[1,2-a]pyridin-3-amine derivatives. The method is based on a two-step approach from acetanilide, 2-chloro-3-formyl quinoline, 2-aminopyridine, and isocyanide under mild reaction conditions. In the first step, acetanilide forms 2-chloroquinoline-3-carbaldehyde in the presence of phosphoryl chloride. The synthesized 2-chloroquinoline-3-carbaldehyde takes part in a multicomponent reaction with 2-aminopyridine, and isocyanide in the presence of trimethylsilyl chloride. The reaction is facile and the products are synthesized in high isolated yields under mild reaction conditions.
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Reference:
Quinoline – Wikipedia,
,Quinoline | C9H7N – PubChem