Day: April 6, 2021

98416-72-9, Name is 6-Bromo-2-chloro-3-methylquinoxaline, belongs to quinoxaline compound, is a common compound. Product Details of 98416-72-9In an article, once mentioned the new application about 98416-72-9.

TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS

The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1989 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 2213-63-0, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 2213-63-0, name is 2,3-Dichloroquinoxaline. In an article£¬Which mentioned a new discovery about 2213-63-0

Synthesis of some new pyrimido[2?,1?:2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents

Treatment of 6-aminothiouracil (1) with 2,3-dichloroquinoxaline (2) in ethanol/TEA afforded 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one (3), which was refluxed in DMF to give 2-aminopyrimido[2?,1?:2,3]thiazolo[4,5-b]quinoxaline-4-one (4). Compound 4 was utilized as a key intermediate for the synthesis of a new pyrimido[2?,1?:2,3]thiazolo[4,5-b]quinoxaline derivatives 5-14 via the reaction with 2-chlorobenzaldehyde, 2-chlorocyclohex-1-enecarbaldehyde, 2-chlorobenzoic acid, 2,4-dichlorobenzoic acid, 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde, 2-chloro-4,6-dimethylnicotinonitrile, alpha,beta-unsaturated ketones and isonicotinaldehyde, respectively. The chemical structures of the newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. These compounds were also screened for their analgesic and anti-inflammatory activities. Some of these compounds (3, 4, 9, 10 and 12-14) exhibited promising activities.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1234 | ChemSpider

Reference of 2213-63-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 2213-63-0, 2,3-Dichloroquinoxaline, introducing its new discovery.

REGIOSELECTIVE SYNTHESIS OF 2,6-DICHLOROQUINOXALINE AND 2-CHLORO-6-IODOQUINOXALINE

Facile regioselective synthesis of 2,6-dichloroquinoxaline and 2-chloro-6-iodoquinoxaline is described.Electrophilic substitution reaction of 2(1H)-quinoxalinone with chloride and iodide ion in 95percent sulfuric acid occurred at 6-position exclusively.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1527 | ChemSpider

Synthetic Route of 1448-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

The Mass Spectra of Halogeno Derivatives of Quinoxaline

The mass spectra of seventeen different quinoxaline halogeno derivatives are reported.The fragmentation mechanism is discussed.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N663 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C8H5ClN2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2

Phosphonium chloride as a non-volatile chlorinating reagent: Preparation and reaction in no solvent or ionic liquid

Reaction of triphenylphosphine with trichloroisocyanuric acid in no solvent or an ionic liquid gave the corresponding phosphonium chloride, which can be used as a cheap and safe chlorinating reagent. Conversion of hydroxyheterocycles to chloroheterocycles, carboxylic acids to carboxylic acid chlorides, and primary amides to nitriles were accomplished by using the phosphonium chloride in excellent to good yields.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N694 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. category: quinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1448-87-9

Design and synthesis of small molecule RhoA inhibitors: A new promising therapy for cardiovascular diseases?

RhoA is a member of Rho GTPases, a subgroup of the Ras superfamily of small GTP-binding proteins. RhoA, as an important regulator of diverse cellular signaling pathways, plays significant roles in cytoskeletal organization, transcription, and cell-cycle progression. The RhoA/ROCK inhibitors have emerged as a new promising treatment for cardiovascular diseases. However, to date, RhoA inhibitors are macromolecules, and to our knowledge, small molecular-based inhibitors have not been reported. In this study, a series of first-in-class small molecular RhoA inhibitors have been discovered by using structure-based virtual screening in conjunction with chemical synthesis and bioassay. Virtual screening of ?200,000 compounds, followed by SPR-based binding affinity assays resulted in three compounds with binding affinities to RhoA at the micromolar level (compounds 1-3). Compound 1 was selected for further structure modifications in considering binding activity and synthesis ease. Fourty-one new compounds (1, 12a-v, 13a-h, and 14a-j) were designed and synthesized accordingly. It was found that eight (12a, 12j, 14a, 14b, 14d, 14e, 14 g, and 14h) showed high RhoA inhibition activities with IC50 values of 1.24 to 3.00 muM. A pharmacological assay indicated that two compounds (14g and 14 h) demonstrated noticeable vasorelaxation effects against PE-induced contraction in thoracic aorta artery rings and served as good leads for developing more potent cardiovascular agents.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N569 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. COA of Formula: C8H4Cl2N2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 2213-63-0, name is 2,3-Dichloroquinoxaline. In an article£¬Which mentioned a new discovery about 2213-63-0

Microwave-assisted dehydration and chlorination using phosphonium salt

Microwave-assisted reaction using phosphonium salt for dehydration of primary amides and chlorination of hydroxyheteroaromatics was carried out. Copyright Taylor & Francis, Inc.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1574 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 2,6-Dichloroquinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 18671-97-1, Name is 2,6-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Antitumor compositions and methods of treatment

This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1632 | ChemSpider

2213-63-0, Name is 2,3-Dichloroquinoxaline, belongs to quinoxaline compound, is a common compound. Product Details of 2213-63-0In an article, once mentioned the new application about 2213-63-0.

Ruthenium(II) complexes of new chelating indolizino[2,3-b]pyrazine- and indolizino[2,3-b]quinoxaline-derived ligands: Syntheses, electrochemistry and absorption spectroscopy

The highly conjugated chelating ligands 5-(2-pyridyl)indolizino[2,3-b] pyrazine 1, 5-(2-pyridyl)indolizino[2,3-b]quinoxaline 2, and 8,9-dimethyl-5-(2-pyridyl)indolizino[2,3-b]quinoxaline 3 were prepared in one step, with good yields, from di-2-pyridylmethane and 2,3-dichloropyrazine, 2,3-dichloroquinoxaline, and 8,9-dimethyl-2,3-dichloroquinoxaline, respectively. Compounds 13 display long-wavelength absorption maxima in the green (1) and yellow (2 and 3) to give intensely coloured red and purple solutions, respectively. Bis(2,2?-bipyridyl)ruthenium(ii) and bis(4,4?- dimethyl-2,2?-bipyridyl)ruthenium(ii) complexes were prepared in moderate to good yields, characterized by NMR spectroscopy and mass spectrometry, and studied by cyclic voltammetry and absorption spectroscopy. Copper(ii) and silver(i) nitrate complexes of the ligands were prepared and complexes [Cu(NO3)2(1)], [Cu(NO3)2(2)] 2, and [Ag(NO3)(3)2] were characterized by X-ray crystallography. These structures revealed the planar nature of the ligands and confirmed the proposed chelating mode.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1563 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2213-63-0, name is 2,3-Dichloroquinoxaline, introducing its new discovery. COA of Formula: C8H4Cl2N2

Cavitands as superior sorbents for benzene detection at trace level

We present an innovative dynamic headspace-based approach to sampling of BTX using molecular receptors. For this purpose methylene-bridged (MeCav) and quinoxaline-bridged (QxCav) cavitands were silylated at the lower rim and grafted onto silica gel. In the case of QxCav, the resulting sorbent material selectively retains BTX at ppb levels in the adsorption phase and delivers a benzene-enriched fraction in the desorption phase. Under the same conditions, commercial sorbents like Carbotrap 100 and Tenax TA proved to be unselective both in the uptake and in the release steps. The molecular origins of the observed selectivity were traced by theoretical calculations in the presence of multiple electrostatic and CH-pi interactions, possible only in the case of QxCav-aromatic analyte complexes.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1273 | ChemSpider