Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of 2,3-Dichloro-6,7-dimethylquinoxaline. Introducing a new discovery about 63810-80-0, Name is 2,3-Dichloro-6,7-dimethylquinoxaline
Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties
The synthesis of six new compounds incorporating either a pyrazino[2,3-b]indolizine or indolizino[2,3-b]quinoxaline core are reported in good yield (58-87%). The intermediates for the key cyclization reaction for one set of compounds (5a-c), with a sterically demanding 3,5-dimethylpyrazole group in the 5-position of the core, were found to be mono-substituted. These intermediates could be isolated and cyclized by heating under acid-catalyzed conditions. To further demonstrate the versatility of the chemistry, compounds 6a-c were synthesized in 58-68% yields. Compounds 5a-c are non-planar in solution and the solid-state, while 6a-c have close to planar conformations, pointing to weak hydrogen bonds between the acidic C-Hs and the adjacent azine nitrogen atoms. The cytotoxicity of the six newly synthesized and three previously prepared compounds was assessed against a human glioblastoma multiforme cell line.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of 2,3-Dichloro-6,7-dimethylquinoxaline, you can also check out more blogs about63810-80-0
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1824 | ChemSpider