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Development of CXCR3 antagonists. Part 4: Discovery of 2-amino-(4-tropinyl)quinolines
The synthesis and biological evaluation of a novel series of 2-aminoquinoline substituted piperidines and tropanes incorporating a homotropene moiety is herein described. The series exhibits potent antagonism of the CXCR3 receptor and superior physicochemical properties. Compound 24d was found to be orally bioavailable, and PK/PD studies suggested it as a suitable tool for studying the role of CXCR3 in models of disease.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N608 | ChemSpider