Day: April 19, 2021

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C8H8N2O, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 59564-59-9

Electrochemical reduction of quinoxalino<2,3-b>quinoxaline: a revised mechanism

The electrochemical reduction of fluoflavine 2 gives compound 9 to which we had previously assigned a hexahydro-quinoxalino<2,3-b>quinoxaline structure.A crystallographic study of a diacetylated derivative of 9 shows that 9 is in fact 2-(o-aminoanilinomethyl)benzimidazole.This result permits us to propose a detailed reduction mechanism for 2 and its diacetyl derivative 25.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N152 | ChemSpider

2213-63-0, Name is 2,3-Dichloroquinoxaline, belongs to quinoxaline compound, is a common compound. COA of Formula: C8H4Cl2N2In an article, once mentioned the new application about 2213-63-0.

Design and discovery of novel quinoxaline derivatives as dual DNA intercalators and topoisomerase II inhibitors

Backgroun/Methods: In attempt to develop new potent anti-tumor agents, a series of quinoxaline derivatives was designed and synthesized. The novel compounds were tested in vitro for their anti-proliferative activities against HePG-2, MCF-7 and HCT-116 cell lines. Additionally, DNA binding affinities as well as DNA-top II inhibitory activities of the synthesized compounds were investigated as potential mechanism for anticancer activity. Compounds 13, 15, 16 and 19 exhibited good cytotoxicity activities against the three cell lines (IC50 ranging from 7.6 to 32.4 muM) comparable to that of doxorubicin (IC50 = 9.8 muM). Results: Interestingly, the results of DNA binding and DNA-top II inhibition assays were in agreement with those of the cytotoxicity tests, where the most potent anticancer compounds showed good DNA binding affinities (IC50 ranging from 25.1 to 32.4 muM) and DNA-top II inhibitory activities (IC50 ranging from 6.4 to 15.3 muM) comparable to those of doxorubicin (IC50 = 28.1 and 3.8 muM, respectively). Furthermore, molecular docking studies were carried out for the new compounds in order to investigate their binding pattern with the prospective target, DNA-top II complex (PDB-code: 3qx3).

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1312 | ChemSpider

Reference of 59564-59-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 59564-59-9, 3,4-Dihydroquinoxalin-2(1H)-one, introducing its new discovery.

Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders

We report the synthesis and structure-activity relationships of a class of tetracyclic butyrophenones that exhibit potent binding affinities to serotonin 5-HT2A and dopamine D2 receptors. This work has led to the discovery of 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl) -1-(4-fluorophenyl)-butan-1-one 4-methylbenzenesulfonate (ITI-007), which is a potent 5-HT2A antagonist, postsynaptic D2 antagonist, and inhibitor of serotonin transporter. This multifunctional drug candidate is orally bioavailable and exhibits good antipsychotic efficacy in vivo. Currently, this investigational new drug is under clinical development for the treatment of neuropsychiatric and neurological disorders.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N171 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 32601-86-8, name is 2-Chloro-3-methylquinoxaline, introducing its new discovery. Application In Synthesis of 2-Chloro-3-methylquinoxaline

Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

From 4 antiplasmodial hit-molecules identified in 2-trichloromethylquinazoline series, we conducted a global Structure-Activity relationship (SAR) study involving 26 compounds and covering 5 molecular regions (I ? V), aiming at defining the corresponding pharmacophore and identifying new bioactive derivatives. Thus, after studying the aniline moiety in detail, thienopyrimidine, quinoline and quinoxaline bio-isosters were synthesized and tested on the K1 multi-resistant P.?falciparum strain, along with a cytotoxicity evaluation on the human HepG2 cell line, to define selectivity indecies. SARs first showed that thienopyrimidines and quinolines were globally more cytotoxic, while quinoxaline analogs appeared as active as- and less cytotoxic than their quinazoline counterparts. Such pharmacomodulation in quinoxaline series not only provided a new antiplasmodial reference hit-molecule (IC50?=?0.4?muM, selectivity index?=?100), but also highlighted an active (IC50?=?0.4?muM) and quite selective (SI?=?265) synthesis intermediate.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1017 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of Quinoxaline-2,3(1H,4H)-dione, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 15804-19-0, name is Quinoxaline-2,3(1H,4H)-dione. In an article£¬Which mentioned a new discovery about 15804-19-0

Synthesis, in vitro antitubercular activity and 3D-QSAR of novel quinoxaline derivatives

Twenty new quinoxalines bearing azetidinone and thiazolidinone groups were synthesized by cyclocondensation of Schiff bases of quinoxaline-2, 3-dione and were characterized with several analytical tools. They were tested against Mycobacterium tuberculosis H37Rv at a concentration of 10mug/mL by Microplate Alamar Blue Assay method. Quinoxaline derivatives with 2-chloro, dimethylamino and nitro substitutions exhibited in vitro activity, comparable to that of the drug, isoniazid. Three-dimensional quantitative structure-activity relationship studies indicated that electrostatic and steric field descriptors could explain the observed activity. The developed model fits the data well and has good predictive capability (r2=0.81, q2=0.71, F=27.06, r2_pred =0.84, r2m =0.84, r2 BS=0.80). Electronegative groups play an important role in the antitubercular activity.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N382 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C8H4Cl2N2. Introducing a new discovery about 2213-63-0, Name is 2,3-Dichloroquinoxaline

Organic Electroluminescent Compounds and Organic Electroluminescent Device Comprising the Same

The present invention refers to organic electro corrosion inhibitor, and water including relates to organic electroluminescence device. The present invention according to organic electroluminescent compounds purity, solubility and as well as good heat stability, whose driving voltage is low, current efficiency and power it has significantly improved operating life a through hole is an organic electroluminescent device of high can be produced. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C8H4Cl2N2, you can also check out more blogs about2213-63-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1195 | ChemSpider

Application of 2213-63-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 2213-63-0, 2,3-Dichloroquinoxaline, introducing its new discovery.

Imidazo[1,2-a]quinoxalines: Synthesis and cyclic nucleotide phosphodiesterase inhibitory activity

A group of imidazo[1,2-a]quinoxalines have been synthesised from quinoxaline by condensation of an appropriate haloester or intramolecular cyclisation of a keto moiety on an intracyclic nitrogen atom. The reactivity of the heterocycle was explored through diverse reactions such as electrophilic substitution, lithiation and halogen-metal exchange to give access to a new series of derivatives. Confirmation of their structure was mainly performed by NMR, after careful assignment of the signals in comparison to previous attributions made on the parent imidazo[1,2-a]quinoxaline and discussion of available data in the literature. The cyclic nucleotide phosphodiesterase inhibitor activity of some of these derivatives has been assessed on isoenzymes type III and type lV. Compound 15, 4-(methylamino)imidazo[1,2-a]quinoxaline-2-carbonitrile, exhibited potent relaxant activity on smooth muscle, with a potency similar to the one measured with SCA 40, its structural analogue in the imidazo[1,2-a]pyrazine series.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1495 | ChemSpider

Synthetic Route of 18671-97-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.18671-97-1, Name is 2,6-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Patent£¬once mentioned of 18671-97-1

Carbamic acid ester herbicides

Carbamic acid ester compounds of the formula STR1 wherein A represents the group (a) or (b) STR2 wherein R1 -R8, X and Y are as defined hereinafter, processes for their preparation, herbicidal compositions containing these compounds and methods for the use of the compounds and the herbicidal compositions are disclosed.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1635 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C8H4Cl2N2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 2213-63-0

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS FOR THE TREATMENT OF CANCER

The invention provides a method for treating endometrial carcinoma comprising administering a Compound of Formula (I) or (II). Also provided is a method for treating breast cancer, comprising administering letrozole in combination with either a Compound of Formula (I) or Formula (II)

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1162 | ChemSpider

Reference of 1448-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

Survey of the electrochemical behavior of chlorinated pyrazines, quinoxalines, and pyridazines at carbon and mercury cathodes

Cyclic voltammetry and controlled-potential electrolysis have been employed to examine the electrochemical behavior of some mono- and dichlorinated pyrazines, quinoxalines, and pyridazines at carbon and mercury cathodes in either acetonitrile or dimethylformamide containing a tetraalkylammonium salt. Unsubstituted pyrazine and pyridazine each exhibit a single reduction wave, whereas unsubstituted quinoxaline shows three cathodic waves. For the chlorinated compounds, an additional wave is seen for the reduction of each carbon-chlorine bond. Depending on the potential of the cathode, bulk electrolyses of dichlorinated pyrazines or quinoxalines afford either the monochlorinated or fully dechlorinated product, whereas the monochlorinated analogues undergo reduction to the dechlorinated species. Electrolyses of chlorinated pyridazines give dark colored solutions, but the products (apparently polymeric) cannot be detected or identified by means of conventional GC, GC-MS, and HPLC techniques.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N640 | ChemSpider