In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 32601-86-8, name is 2-Chloro-3-methylquinoxaline, introducing its new discovery. Application In Synthesis of 2-Chloro-3-methylquinoxaline
Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold
From 4 antiplasmodial hit-molecules identified in 2-trichloromethylquinazoline series, we conducted a global Structure-Activity relationship (SAR) study involving 26 compounds and covering 5 molecular regions (I ? V), aiming at defining the corresponding pharmacophore and identifying new bioactive derivatives. Thus, after studying the aniline moiety in detail, thienopyrimidine, quinoline and quinoxaline bio-isosters were synthesized and tested on the K1 multi-resistant P.?falciparum strain, along with a cytotoxicity evaluation on the human HepG2 cell line, to define selectivity indecies. SARs first showed that thienopyrimidines and quinolines were globally more cytotoxic, while quinoxaline analogs appeared as active as- and less cytotoxic than their quinazoline counterparts. Such pharmacomodulation in quinoxaline series not only provided a new antiplasmodial reference hit-molecule (IC50?=?0.4?muM, selectivity index?=?100), but also highlighted an active (IC50?=?0.4?muM) and quite selective (SI?=?265) synthesis intermediate.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 32601-86-8, and how the biochemistry of the body works.Application In Synthesis of 2-Chloro-3-methylquinoxaline
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1017 | ChemSpider