In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of Quinoxaline-2,3(1H,4H)-dione, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 15804-19-0, name is Quinoxaline-2,3(1H,4H)-dione. In an article£¬Which mentioned a new discovery about 15804-19-0
Synthesis, in vitro antitubercular activity and 3D-QSAR of novel quinoxaline derivatives
Twenty new quinoxalines bearing azetidinone and thiazolidinone groups were synthesized by cyclocondensation of Schiff bases of quinoxaline-2, 3-dione and were characterized with several analytical tools. They were tested against Mycobacterium tuberculosis H37Rv at a concentration of 10mug/mL by Microplate Alamar Blue Assay method. Quinoxaline derivatives with 2-chloro, dimethylamino and nitro substitutions exhibited in vitro activity, comparable to that of the drug, isoniazid. Three-dimensional quantitative structure-activity relationship studies indicated that electrostatic and steric field descriptors could explain the observed activity. The developed model fits the data well and has good predictive capability (r2=0.81, q2=0.71, F=27.06, r2_pred =0.84, r2m =0.84, r2 BS=0.80). Electronegative groups play an important role in the antitubercular activity.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 15804-19-0, help many people in the next few years.Application In Synthesis of Quinoxaline-2,3(1H,4H)-dione
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N382 | ChemSpider