Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of 2-Chloroquinoxaline. Introducing a new discovery about 1448-87-9, Name is 2-Chloroquinoxaline
The Reaction of 2-Chloroquinoxaline with Piperidine in DMSO?H2O and DMF?H2O Mixtures: Kinetics and Solvent Effects
The rate constant of the reaction of 2-chloroquinoxaline with piperidine was measured spectrophotometrically using different aqueous solutions containing DMSO or DMF. Whatever the experimental conditions used, this reaction follows pseudo first order kinetics and is not amine catalyzed. Furthermore, the second order rate constant, kA, increases with increasing percentage of DMSO in the solution, in contrast to DMF. The kA values were then correlated with solvent parameters alpha, beta, pi*, ETN and Y. Plots of log10kA against the reciprocal of the dielectric constant at 25 C were found to be nonlinear in DMSO, while a linear relationship with a negative slope was found in the case of DMF. This difference between the solvents is presumably due to different solvation pathways between their initial and transition states. Thus, activation parameters DeltaHNo., DeltaSNo. and DeltaGNo. were evaluated and discussed to support this hypothesis. Finally, DFT calculations were performed, using the B3LYP functional and 6-311G(d,p) basis set, to determine optimum molecular geometry. IR, NMR spectra for both reactant and product and were then compared with experimental values.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 2-Chloroquinoxaline, you can also check out more blogs about1448-87-9
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N581 | ChemSpider