Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 17056-99-4. Introducing a new discovery about 17056-99-4, Name is Quinoxalin-5-ol
Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists
A high throughput screening approach to the identification of selective cholecystokinin-2 receptor (CCK-2R) ligands resulted in the discovery of a novel series of antagonists, represented by 1-[2-[(2,1,3-benzothiadiazol-4- ylsulfonyl)amino]-5-chlorobenzoyl]-piperidine (1; CCK-2R, pKI = 6.4). Preliminary exploration of the structure-activity relationships around the anthranilic ring and the amide and sulfonamide moieties led to a nearly 50-fold improvement of receptor affinity and showed a greater than 1000-fold selectivity over the related cholecystokinin-1 receptor. Pharmacokinetic evaluation led to the identification of 4-[4-iodo-2-[(5-quinoxalinylsulfonyl)amino]benzoyl]- morpholine, 26d, a compound that demonstrates promising pharmacokinetic properties in the rat and dog with respect to plasma clearance and oral bioavailability and is a potent inhibitor in vivo of pentagastrin-stimulated acid secretion in the rat when dosed orally.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 17056-99-4, you can also check out more blogs about17056-99-4
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N108 | ChemSpider