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Enatioselective Synthesis of Tetrahydrocarbazoles via Chiral Phosphoric Acid Promoted Domino Friedel?Crafts-type Reaction of Indole-3-butanal with Indoles
By employing a chiral phosphoric acid as a catalyst, enantioselective domino Friedel?Crafts-type reaction of indole-3-butanal with indoles was realized. This transformation allowed for the synthesis of a wide variety of enantioenriched 1-indolyl-tetrahydrocarbazoles with good yields (up to 99%) in moderate enantioselectivities (up to 81% ee).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 5-Nitroquinoxaline, you can also check out more blogs about18514-76-6
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N929 | ChemSpider