Month: May 2021

Synthetic Route of 2213-63-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a article，once mentioned of 2213-63-0

A systematic study of the synthesis and properties of 1-aza-, 4-aza-, and 1,4-diaza[4]helicenes as well as the previously unknown S-shaped double 1,4-diaza[4]helicenes has been reported. The synthetic route to the aza- and diaza[4]helicenes involved an electrophile-induced cyclization of 3(2)-alkynyl-2(3)-(naphthalen-1-yl)azines (i.e., quinoxaline, pyrazine, pyridine), which were prepared in two steps from the commercially available ortho-dihalo-substituted azine. Trifluoroacetic acid (TFA) and ICl were used as electrophiles. The ICl-promoted cyclization provided the 5-iodo derivatives of the aza- and diaza[4]helicenes in yields of 47?71 %. The use of TFA as the electrophile afforded the helicenes along with isomeric products from an alternative cyclization and subsequent 1,2-shift of the C?C bond (e.g., naphtho[2,1-f]quinoxalines or naphtho[2,1-a]phenazines, 87?89 % total yield, 1.5?1.8:1 ratio). The presence of an iodine substituent in the hetero[4]helicenes allowed for the introduction of an alkynyl group by using a Sonogashira reaction. The subsequent cycloizomerization upon treatment with TFA gave the S-shaped double 1,4-diaza[4]helicenes. The molecular structures and crystal packing of the synthesized hetero[4]helicenes relative to those of [4]carbohelicene have been discussed.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1343 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 82031-32-1, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 82031-32-1, name is 7-Bromoquinoxalin-2(1H)-one. In an article，Which mentioned a new discovery about 82031-32-1

A photocatalyst-free visible-light-promoted sulfenylation of quinoxalinones with thiols via cross-dehydrogenative coupling was developed. This protocol allowed the direct formation of diverse 3-sulfenylquinoxalin-2(1H)-ones under metal- and catalyst-free conditions and using air (O2) as an oxidant. Furthermore, a range of readily accessible thiols and quinoxalin-2(1H)-ones was applied in this coupling, resulting in an attractive process of accessing 3-substituted quinoxalinones.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1792 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 55687-23-5, name is 6-Fluoroquinoxalin-2(1H)-one, introducing its new discovery. Recommanded Product: 6-Fluoroquinoxalin-2(1H)-one

Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula (I) including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N433 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 6925-00-4, name is Quinoxaline-6-carboxylic acid, introducing its new discovery. Quality Control of Quinoxaline-6-carboxylic acid

A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles (15a-l) have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 4-[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]b enzenesulfonamide (15b) and 4-[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]be nzenesulfonamide (15c) showed more than 90% inhibition at 0.5 muM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct, but inhibited p38alpha MAP kinase activity only 11 and 8% at a concentration of 10 muM, respectively.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N807 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 67074-63-9, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 67074-63-9

A practical and highly efficient route to the synthesis of pharmaceutically interesting quinoxalinone scaffolds is reported. The key step involves an intramolecular palladium-catalyzed N-arylation under microwave irradiation. The developed methodology tolerates a variety of bromoanilides to afford a diverse collection of bicyclic and polycyclic quinoxalinones in high yield.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N426 | ChemSpider

Reference of 1448-87-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article，once mentioned of 1448-87-9

A mild and efficient alpha-heteroarylation of simple esters and amides was developed via nucleophilic aromatic substitution. The choice of NaHMDS in toluene gave the best results. A tandem alpha-heteroarylation and hydroxylation protocol using air as the oxidant afforded tertiary alcohols in good yields.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N684 | ChemSpider

Related Products of 2379-56-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2379-56-8, Name is 6-Nitroquinoxaline-2,3-dione, molecular formula is C8H3N3O4. In a Article，once mentioned of 2379-56-8

This paper describes the design and synthesis of a new class of molecules, the 3-sulfonylamino-2-(1H)-quinolones, which are potent and selective antagonists at both the AMPA/kainate site as well as at the NMDA-associated glycine site. The molecules were characterized by their binding affinities to rat cortical membranes and by electrophysiology on Xenopus oocytes injected with mRNA isolated from rat cerebral cortex. The most potent compound 61 has an IC50 of 0.09 muM for binding at the AMPA/kainate site, and 0.16 muM in oocyte electrophysiology.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1699 | ChemSpider

2213-63-0, Name is 2,3-Dichloroquinoxaline, belongs to quinoxaline compound, is a common compound. Application In Synthesis of 2,3-DichloroquinoxalineIn an article, once mentioned the new application about 2213-63-0.

The Knudsen mass-loss effusion technique was used to measure the vapor pressures at different temperatures of the following substituted quinoxalines: 2-hydroxyquinoxaline, between 383.17 K and 399.15 K; 2-hydroxy-3-methylquinoxaline, between 375.16 K and 391.15 K; 2,3-dichloroquinoxaline, between 313.15 K and 329.15 K; 2,3,6,7-tetrachloroquinoxaline, between 347.16 K and 361.17 K; 2,3-dimethylquinoxaline between 294.14 K and 308.14 K; 2,3-bis(bromomethyl)quinoxaline, between 351.14 K and 365.14 K. From the temperature dependence of the vapor pressure, the standard molar enthalpies of sublimation at the mean temperature of the experimental range were derived by the Clausius-Clapeyron equation. From these results the standard molar enthalpies, entropies, and Gibbs functions of sublimation at T = 298.15 K were calculated. An empirical equation for estimating vapor pressure-temperature data from enthalpies of sublimation values is presented.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1468 | ChemSpider

Synthetic Route of 17056-99-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 17056-99-4, Name is Quinoxalin-5-ol, molecular formula is C8H6N2O. In a Article，once mentioned of 17056-99-4

The synthesis and structure-activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36, a potent gp120-CD4 inhibitor which exhibited antiviral potency across a spectrum of 25 clade B isolates.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N117 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 59564-59-9, name is 3,4-Dihydroquinoxalin-2(1H)-one, introducing its new discovery. Quality Control of 3,4-Dihydroquinoxalin-2(1H)-one

Iron(III) tetraphenylporphyrin chloride, Fe(TPP)Cl, efficiently catalyzed the insertion of carbenes derived from methyl 2-phenyldiazoacetates into O-H bonds of aliphatic and aromatic alcohols, with yields generally above 80%. Although the analogous N-H insertions are rapid at room temperature, the O-H insertion reactions are slower and required heating in refluxing methylene chloride for about 8 hours using 1.0 mol.% catalyst. Fe(TPP)Cl was also found to be effective for tandem N-H insertion/cyclization reactions when 1,2-diamines and 1,2-alcoholamines were treated with diazo reagents to give piperazinones and morpholinones and related analogs such as quinoxalinones and benzoxazin-2-ones. This approach provides a new one-pot route for synthesizing these classes of heterocyclic compounds.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N172 | ChemSpider