Day: June 2, 2021

Related Products of 2379-56-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2379-56-8, Name is 6-Nitroquinoxaline-2,3-dione, molecular formula is C8H3N3O4. In a Article，once mentioned of 2379-56-8

We have developed a novel fluorescent scaffold 4 which is a 9-nitro-2,3-dihydro-1H-pyrimido[1,2-a]quinoxalin-5-amine derivative from the reaction between di-tert-butyl but-2-ynedioate and a quinoxaline molecule containing a dimethyl amine side tail in high yield. The synthesis of scaffold 4 involves an sp3 C-N bond cleavage mechanism which is not very common. The scaffolds 4 is emissive in the visible range lambdaem ? (517-540) nm with large stokes shifts (5005-6378) cm-1 in ethanol. Laser confocal microscopy of the live HepG2 cells treated with compound 4f shows that it can be used for live cell imaging in nanomolar concentrations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 2379-56-8. In my other articles, you can also check out more blogs about 2379-56-8

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1704 | ChemSpider

1448-87-9, Name is 2-Chloroquinoxaline, belongs to quinoxaline compound, is a common compound. COA of Formula: C8H5ClN2In an article, once mentioned the new application about 1448-87-9.

The oxidation reaction of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described.Neutral oxidation of 2-chloro- and 2,3-dichlorodioxalines 2-4 afforded the corresponding chloro- and dichloropyrazinedicarboxilic acids 13 and 14 in good yield.On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alkaline medium gave different products, with the quinoxalin-2(1H)-one (5) forming 1,4-dihydroquinoxaline-2,3-dione (9), while various substituted quinoxalin-2,3-dione derivatives (see 9-11) gave a new type of dimeric products.The structural assignments for the new compounds were based on spectroscopic data.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N649 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 2,3-Dichloroquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 2213-63-0

2,3-Dichloroquinoxaline has been cyclo-condensed with 2-aminopyridine, 2-aminothiazoles, 2-aminothiadiazoles, 2-aminobenzimidazole and 2-mercaptobenzimidazole to give the corresponding novel heterocyclic systems.The reaction of 2,3-dichloroquinoxaline with thioacetamide has also been studied.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1321 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C9H7BrN2O, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 82019-32-7

A novel and efficient approach to the C(sp2)?H/C(sp3)?H oxidative coupling of quinoxalin-2(1H)-ones with methylarenes by using CuI as catalyst is reported. Various substrates were well tolerated in this methodology and the desired products were given in moderate-to-good yields. This reaction features good functional group compatibility and broad substrate scope.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1923 | ChemSpider

6344-72-5, Name is 6-Methylquinoxaline, belongs to quinoxaline compound, is a common compound. Formula: C9H8N2In an article, once mentioned the new application about 6344-72-5.

Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein trimethyl orthoformate, a common laboratory solvent, serves as a methyl source. This method permits methylation of (hetero)aryl chlorides and acyl chlorides at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that trimethyl orthoformate serves as a source of methyl radical via beta-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N21 | ChemSpider

Application of 41213-32-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 41213-32-5, Name is 2-Chloro-6-(trifluoromethyl)quinoxaline,introducing its new discovery.

A cyanoketone derivative of the following formula (1) STR1 wherein A1 is a substituted or unsubstituted phenyl or naphthyl group or a substituted or unsubstituted heterocyclic group; each of X1, X2 and X3 is independently an oxygen or sulfur atom; each of B1, B2 and B3 is independently a hydrogen atom or C1 -C6 -alkyl group; each of Y1, Y2, Y3 and Y4 is independently a hydrogen atom, a halogen atom or a C1 -C6 -alkyl group; and A2 is a substituted or unsubstituted group selected from the group consisting of a C1 -C6 -alkyl group, a C2 -C6 -alkenyl group, a C2 -C6 -alkynyl group, a C1 -C4 -alkoxy group, a C1 -C4 -alkylthio group, a C1 -C6 -alkoxycarbonyl group, an unsubstituted benzoyl group, a halogen-substituted benzoyl group, a cyano group or a group as defined in A1 ; provided that when B1 is a hydrogen atom and B2 is alkyl, the compound of the formula (1) is an R- or S-enantiomer with regard to asymmetric carbon to which B1 and B2 are bonded, or a mixture of these enantiomers. The cyanoketone derivative has a remarkably high herbicidal activity and is effective against a variety of gramineous weeds.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1857 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C8H6N2O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2

New series of [1,2,4]triazolo [4,3-a]quinoxaline and bis([1,2,4]triazolo)[4,3-a:3?,4?-c]quinoxaline derivatives have been designed, synthesized and biologically evaluated for their cytotoxic activities against three tumor cell lines (HePG-2, Hep-2 and Caco-2). Compounds 16e, 21, 25a and 25b exhibited the highest activities against the examined cell lines with IC50 values ranging from 0.29 to 0.90 muM comparable to that of doxorubicin (IC50 ranging from 0.51 to 0.73 muM). The most active members were further evaluated for their topoisomerase II (Topo II) inhibitory activities and DNA intercalating affinities as potential mechanisms for their anti-proliferative activities. Interestingly, the results of Topo II inhibition and DNA binding assays were consistent with that of the cytotoxicity data, where the most potent anti-proliferative derivatives exhibited good Topo II inhibitory activities and DNA binding affinities, comparable to that of doxorubicin. Moreover, the most active compound 25a caused cell cycle arrest at G2/M phase and induced apoptosis in Caco-2 cells. In addition, Furthermore, molecular docking studies were performed for the novel compounds against DNA-Topo II complex to investigate their binding patterns. Based on these studies, it was concluded that DNA binding and/or Topo II inhibition may contribute to the observed cytotoxicity of the synthesized compounds.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N332 | ChemSpider

Reference of 6640-47-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 6640-47-7, Name is Quinoxaline-2,3-diamine,introducing its new discovery.

Three new alpha,alpha?-diimine ligands were synthesized based on condensation of 1,10-phenanthroline-5,6-dione with 1,2-phenylenediamine derivatives using different approaches. All compounds were fully characterized by IR, 1H and 13C NMR, UV-visible, and MS spectroscopies. We report the first example of a dipyrido[3,2-f:2?,3?-h]quinoxalino[2,3-b]quinoxaline, which exhibits a strong absorption at 430 nm and an interesting electrochemical behavior. These new molecules may have biological potential and are of synthetic and technological importance.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N254 | ChemSpider

Electric Literature of 59564-59-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.59564-59-9, Name is 3,4-Dihydroquinoxalin-2(1H)-one, molecular formula is C8H8N2O. In a Article，once mentioned of 59564-59-9

In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/IIa HDACs. The observed selectivity and potency (IC50 values 10-200 nM against HDAC6) is markedly dependent on the absolute configuration of the chiral moiety, and suggests new possibilities for use of chiral compounds in selective HDAC isoform inhibition.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N188 | ChemSpider

Reference of 1448-87-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1448-87-9, Name is 2-Chloroquinoxaline,introducing its new discovery.

Reaction of 2-chloroquinoxaline (1) with O-potassio-3,3-dimethyl-2-butanone (2) in liquid NH3 affords 1-(quinoxalin-2-yl)-3,3-dimethyl-2-butanone (3) via a thermal SRN1 mechanism and 2-tert-butylfuro<2,3-b>quinoxaline (4) via a competing ionic, addition-substitution process.When the SRN1 component of this … scheme is inhibited by di-tert-butyl nitroxide, only furoquinoxaline 4 is produced.O-Potassio-2,4-dimethyl-3-pentanone (5) reacts in a similar fashion with 1 to give SRN1 products, 2-(quinoxalin-2-yl)-2,4-dimethyl-3-pentanone (6) and 2-isopropylquinoxaline (8), along with quinoxalino<3,4-b>-2,2,5,5-tetramethylcyclopentanone (7), which results from addition-substitution.Reaction of 1 with O-potassio-3-methyl-2,4-pentanedione (9) affords low yields of 2-(quinoxalin-2-yl)butanone (10) by a sluggish SRN1 pathway.Reactions of 4-chloroquinazoline (11a) and 4-chloro-2-phenylquinazoline (11b) with enolate 2 provide excellent yields of the respective 4-quinazolinyl ketones 12a,b via an apparent SNAr mechanism.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N542 | ChemSpider