Reference of 1448-87-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1448-87-9, Name is 2-Chloroquinoxaline,introducing its new discovery.
Reaction of 2-chloroquinoxaline (1) with O-potassio-3,3-dimethyl-2-butanone (2) in liquid NH3 affords 1-(quinoxalin-2-yl)-3,3-dimethyl-2-butanone (3) via a thermal SRN1 mechanism and 2-tert-butylfuro<2,3-b>quinoxaline (4) via a competing ionic, addition-substitution process.When the SRN1 component of this … scheme is inhibited by di-tert-butyl nitroxide, only furoquinoxaline 4 is produced.O-Potassio-2,4-dimethyl-3-pentanone (5) reacts in a similar fashion with 1 to give SRN1 products, 2-(quinoxalin-2-yl)-2,4-dimethyl-3-pentanone (6) and 2-isopropylquinoxaline (8), along with quinoxalino<3,4-b>-2,2,5,5-tetramethylcyclopentanone (7), which results from addition-substitution.Reaction of 1 with O-potassio-3-methyl-2,4-pentanedione (9) affords low yields of 2-(quinoxalin-2-yl)butanone (10) by a sluggish SRN1 pathway.Reactions of 4-chloroquinazoline (11a) and 4-chloro-2-phenylquinazoline (11b) with enolate 2 provide excellent yields of the respective 4-quinazolinyl ketones 12a,b via an apparent SNAr mechanism.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1448-87-9, and how the biochemistry of the body works.Reference of 1448-87-9
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N542 | ChemSpider