Archives for Chemistry Experiments of 2-Chloro-7-nitroquinoxaline

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Methodologies to obtain quinoxaline compounds regioselectively are rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives are desirable to explore the entire potential of these scaffolds for academic and/or commercial application. A facile and multi-gram methodology is described to obtain compound 7-nitroquinoxalin-2-amine using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatography.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1734 | ChemSpider