Recommanded Product: 6925-00-4, New research progress on 6925-00-4 in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.6925-00-4, Name is Quinoxaline-6-carboxylic acid, molecular formula is C9H6N2O2. In a article，once mentioned of 6925-00-4
We here report the synthesis of compounds structurally related to the high-affinity dopamine D3 receptor ligand N-[4-[4-(2,3- dichlorophenyl)piperazin-1-yl]butyl]-7-methoxy-2-benzofurancarboxamide (1). All compounds were specifically designed as potential PET radioligands for brain D3 receptors visualization, having lipophilicity within a range for high brain uptake and weak nonspecific binding (2 < ClogP < 3.5) and bearing a methoxy substituent for easy access to labeling with the positron emitter isotope 11C. N-[4-[4-(5-methoxy-2-benzisoxazolyl) piperazin-1-yl]butyl]-4-(4-morpholinyl)benzamide (22), N-[4-[4-(5-methoxy-2- benzisoxazolyl)piperazin-1-yl]butyl]-4-(1H-imidazol-1-yl)benzamide (23), and N-[4-[4-(5-methoxy-2-benzisoxazolyl)piperazin-1-yl]butyl]-5-(2-furanyl) -1H-pyrazole-3-carboxamide (24) displayed good D3 receptor affinities (Ki values 38.0, 22.6, and 21.3 nM, respectively) and were selective over D2 receptor. Moreover, compounds 22-24 were able to permeate the Caco-2 cell monolayer, differently from compound 1. Although the goal to identify potential PET radioligands with subnanomolar affinities for D 3 receptor was not achieved, the proposed strategy could be a starting point for future developments. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 6925-00-4, you can also check out more blogs about6925-00-4
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N808 | ChemSpider