Day: July 30, 2021

New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Computed Properties of C9H7ClN2, In a article, mentioned the application of 32601-86-8, Name is 2-Chloro-3-methylquinoxaline, molecular formula is C9H7ClN2

The synthesis and characterization of 14 monometallic derivatives of quinoline, quinoxaline, quinazoline and tetraazolo<1,5-A>quinoline and a bimetallic derivative of quinoxaline are reported. These species were prepared in 11 to 88% isolated yields by metathesis reactions between NaFp or NaFp? (where Fp = (eta5 – C5H5)Fe(CO)2 and Fp? = (eta5 – indenyl)Fe(CO)2 ) and the appropriate chlorine substituted polyaromatic azines. These reactions are highly regioselective and generally produce a single organometallic product having the organometallic substituent(s) bonded to the more highly activated azine ring. The structures of three representative examples were confirmed by their X-ray crystal structures, which are reported for the title complexes 4-[(eta5-cyclopentadienyl)irondicarbonyl]-7-chloroquinoline (C16H10ClFeNO2; a = 7.608(1)A, b = 12.006(1)A, c = 15.664(1)A, V = 1431A3; orthorhombic; P212121; Z =4), 2-[(eta5-cyclopentadienyl)irondicarbonyl]-3-chloroquinoxaline (C15H9ClFeN2O2; a = 15.291(3) A, b = 6.561(2) A, c = 14.541(4) A, beta = 106.891(21), V= 1395.9A3; monoclinic; P21/c; Z = 4), and 2-[(eta5-indenyl)irondicarbonyl]-3-chloroquinoxaline (C19H11ClFeN2O2; a = 19.131(2)A, b = 6.688(1)A, c = 13.515(2) A, beta= 101.569(11), V = 1694.1 A3; monoclinic; P21/c; Z = 4). The bimetallic quinoxaline derivative 2,3-[(C5H5)2Fe2(CO)4]-quinoxaline has orrto-substituted organometallic groups and the spectroscopic data suggest that it has an unusual structure in solution, perhaps involving bridging cyclopentadienyl and carbonyl ligands.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1030 | ChemSpider

New Advances in Chemical Research, May 2021. In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application of 18514-76-6, We’ll be discussing some of the latest developments in chemical about CAS: 18514-76-6, name is 5-Nitroquinoxaline. In an article，Which mentioned a new discovery about 18514-76-6

An efficient methodology is described and exploited for the preparation of differently substituted indoles and azaindoles via microwave-assisted cycloisomerization in water of 2-alkynylanilines and alkynylpyridinamines, which is promoted by catalytic amounts of neutral or basic salts or by stoichiometric weak organic bases. Good to high yields in the cyclization can be achieved for a variety of 2-amino(hetero)aryl alkynes. Reactions are run without any added metal catalyst. A comparison with the cycloisomerization conducted under conventional heating is also described. An efficient methodology is described for the preparation of differently substituted 1H-indoles and 1H-azaindoles via microwave-assisted cycloisomerization in water of 2-alkynylanilines and alkynylpyridinamines, promoted by catalytic amounts of neutral or basic salts or by weak organic bases.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N839 | ChemSpider

New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.Product Details of 2213-63-0, In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1169 | ChemSpider

category: quinoxaline, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 55686-94-7, Name is 2-Chloro-7-nitroquinoxaline, molecular formula is C8H4ClN3O2. In a article，once mentioned of 55686-94-7

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions – I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety – to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1735 | ChemSpider

New Advances in Chemical Research, May 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. Related Products of 6640-47-7, In a article, mentioned the application of 6640-47-7, Name is Quinoxaline-2,3-diamine, molecular formula is C8H8N4

The electrochemical oxidation of phenols and their alkyl ethers not containing strong electron-withdrawing substituents in fluorosulfonic acid takes place in the form of the benzenonium ions and is irreversible in character.With the introduction of substituents of the -M type into the benzene ring the oxidation process affects the unprotonated molecules to a first approximation and in many cases goes reversibly to the radical-cations.Comparison of the oxidation potentials of the substrates in acetonitrile and fluorosulfonic acid made it possible to reveal certain characteristics of the fine structure of these radical-cations, which is determined by the ability of the latter to interact with the medium.Heterocyclic cations whose oxidation potentials in acetonitrile lie beyond the limit of the discharge of the supporting electrolyte can be oxidized in fluorosulfonic acid.Cations of the quinolinium, isoquinolinium, acridinium, acridizinium, imidazolium, and other series, which have irreversible many-electron waves in acetonitrile, give well-defined reversible peaks for oxidation to the corresponding radical-dications in fluorosulfonic acid.In phenyl- and benzyl-substituted cations the substituents and not the positively charged heterocycle itself can undergo oxidation.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N261 | ChemSpider

Application of 82031-32-1, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 82031-32-1, Name is 7-Bromoquinoxalin-2(1H)-one, molecular formula is C8H5BrN2O. In a article，once mentioned of 82031-32-1

A novel quinoxalinamine-containing fluorescent probe (LK) was designed and synthesized based on coordination for real-time detection of Pd2+. LK was easily obtained in high yield by the Suzuki cross-coupling reaction. The quinoxaline group provides the sensor LK with good water-solubility, which is important for monitoring in biological systems. The probe possessed large Stokes shifts and excellent selectivity for detecting Pd2+ in the presence of various potential interfering metal ions. The detection limit (22 nM) was far lower than the criterion of the World Health Organization in drinking water. Moreover, LK displayed high sensitivity for identification of Pd2+ in real water samples. More importantly, the sensor LK succeeded in imaging detection of Pd2+ in live cells with good membrane permeability and low toxicity.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1788 | ChemSpider

Related Products of 2213-63-0, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a article，once mentioned of 2213-63-0

The proton sponge-triethylamine tris(hydrogen fluoride) mixture provides a mild and efficient fluorinating – reagent for the selective introduction of a fluorine atom, by halogen exchange, into dichlorodiazines. (C) 2000 Elsevier Science Ltd.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1300 | ChemSpider

New Advances in Chemical Research, May 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing theoretical assessments of solvent structures and their interactions with reaction intermediates. SDS of cas: 6298-37-9, We’ll be discussing some of the latest developments in chemical about CAS: 6298-37-9, name is Quinoxalin-6-amine. In an article，Which mentioned a new discovery about 6298-37-9

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N79 | ChemSpider

New Advances in Chemical Research, May 2021. In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 59564-59-9, We’ll be discussing some of the latest developments in chemical about CAS: 59564-59-9, name is 3,4-Dihydroquinoxalin-2(1H)-one. In an article，Which mentioned a new discovery about 59564-59-9

A new series of 4-acetyl-1-substituted-3,4-dihydroquinoxalin-2(1H)-ones (2?13) were designed and synthesized in order to evaluate their AMPA-receptor antagonism as a potential mode of anticonvulsant activity. The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1HNMR, 13CNMR and Mass). The molecular design was performed for all the synthesized compounds to predict their binding affinity to AMPA-receptor in order to rationalize their anticonvulsant activity in a qualitative way. The data obtained from the molecular modeling was strongly correlated with that obtained from the biological screening which revealed that; compounds 12b, 13, 12a and 7a showed the highest binding affinities toward AMPA-receptor and also showed the highest anticonvulsant activities against pentylenetetrazole -induced seizures in experimental mice. The relative potencies of these compounds were 1.66, 1.66, 1.61 and 0.82 respectively, in comparing to diazepam.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N161 | ChemSpider

New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Synthetic Route of 15804-19-0, In a article, mentioned the application of 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2

The reaction of 2,3-dichloroquinoxaline (1) with various acid hydrazides (II) in 1:2 mole ratio using HMPT as solvent gives the corresponding ditriazoloquinoxalines (IV) in excellent yields while equimolar quantities of I and II react together in acetonitrile/K2CO3 under PTC conditions to form the respective oxadiazinoquinoxalines (V) as exclusive reaction products in good yields.The reaction mechanisms and spectral data of IV and V are also reported.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N390 | ChemSpider