COA of Formula: C9H10N2O, New research progress on 67074-63-9 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.67074-63-9, Name is 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one, molecular formula is C9H10N2O. In a article，once mentioned of 67074-63-9
Preclinical antithrombotic efficacy and bleeding models have demonstrated that P2Y1 antagonists are efficacious as antiplatelet agents and may offer a safety advantage over P2Y12 antagonists in terms of reduced bleeding liabilities. In this article, we describe the structural modification of the tert-butyl phenoxy portion of lead compound 1 and the subsequent discovery of a novel series of conformationally constrained ortho-anilino diaryl ureas. In particular, spiropiperidine indoline-substituted diaryl ureas are described as potent, orally bioavailable small-molecule P2Y1 antagonists with improved activity in functional assays and improved oral bioavailability in rats. Homology modeling and rat PK/PD studies on benchmark compound 3l will also be presented. Compound 3l was our first P2Y1 antagonist to demonstrate a robust oral antithrombotic effect with mild bleeding liability in the rat thrombosis and hemostasis models.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C9H10N2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 67074-63-9, in my other articles.
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N427 | ChemSpider