Extracurricular laboratory:new discovery of 5-Nitroquinoxaline

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application In Synthesis of 5-Nitroquinoxaline, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 18514-76-6

New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Application In Synthesis of 5-Nitroquinoxaline, In a article, mentioned the application of 18514-76-6, Name is 5-Nitroquinoxaline, molecular formula is C8H5N3O2

We report the synthesis and the affinity data at both the peripheral (PBR) and the central benzodiazepine receptors of a series of N,N-dialkyl-2-phenylindol-3-ylglyoxylamide derivatives III, designed as conformationally constrained analogues of 2-phenylindole-3-acetamides II such as FGIN-1-27. Most of the new compounds showed a high specificity and affinity for PBR, with Ki in the nanomolar to subnanomolar range. The most potent ligands (4-7, 9, 13-27) stimulated steroid biosynthesis in rat C6 glioma cells with a potency similar to or higher than that of classical ligands. The SARs of this new class of compounds are discussed.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application In Synthesis of 5-Nitroquinoxaline, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 18514-76-6

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N894 | ChemSpider