Day: August 26, 2021

New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.Safety of 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione, In a article, mentioned the application of 25983-13-5, Name is 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione, molecular formula is C8H4Cl2N2O2

New drugs are introduced to the market every year and each represents a privileged structure for its biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of 26 NCEs that were launched in the world in 2011.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1848 | ChemSpider

New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.Safety of 7-Bromoquinoxalin-2(1H)-one, In a article, mentioned the application of 82031-32-1, Name is 7-Bromoquinoxalin-2(1H)-one, molecular formula is C8H5BrN2O

The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1771 | ChemSpider

Synthetic Route of 6924-66-9, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 6924-66-9, Name is Quinoxaline-5-carboxylic acid, molecular formula is C9H6N2O2. In a article，once mentioned of 6924-66-9

Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication and is a prime target for the discovery of new treatment options. We recently disclosed 1H-benzo[de]isoquinoline-1,3(2H)-diones as allosteric inhibitors of NS5B Polymerase. Structural and SAR information guided us in the modification of the core structure leading to new templates with improved activity and toxicity/activity window.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N776 | ChemSpider

Electric Literature of 6639-87-8, New research progress on 6639-87-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2. In a Patent，once mentioned of 6639-87-8

The present invention relates to a compound of formula: (I) or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing a viral infection such as HIV using the same.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N938 | ChemSpider

Synthetic Route of 6639-87-8, New research progress on 6639-87-8 in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2. In a article，once mentioned of 6639-87-8

(Chemical Equation Presented) 1,4-Diethyl-1,2,3,4-tetrahydro-6- nitroquinoxaline 4 was synthesized by alkylative reduction of 6-nitroquinoxaline. Catalytic reduction of 4 followed by cyclocondensation with heterocyclic malondialdehydes afforded novel 8-(heteroaryl)-1,4-diethyl-1,2,3,4- tetrahydropyrido[2,3-g]quinoxalines. The solutions of these novel compounds having 1,4-diethyl-1,2,3,4-tetrahydroquinoxaline framework as an electron releasing system showed absorption in the range of 424-426 nm in the visible region and exhibited brilliant bluish-green fluorescence. The thermogravimetric curve obtained by thermogravimetric analysis displayed that these fluorophores possess excellent thermal stability with one-step thermal decomposition.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N967 | ChemSpider

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1448-87-9, In a article, mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2

Novel 1,4-diazine-based dyes of the D?pi?A type, possessing triphenylamine as an electron-donating group, have been developed. Fluorescence studies have demonstrated that emission of these fluorophores is sensitive towards different nitroaromatic compounds and aliphatic amines, both in solutions and in a vapor phase. Moreover, these compounds can be considered as ?naked-eye? fluorescent probes for solution polarity because they possess pronounced solvatochromic properties. Therefore, these compounds have to be regarded as potential multifunctional chemosensors for monitoring hazardous organic substances.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N521 | ChemSpider

Reference of 1448-87-9, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a article，once mentioned of 1448-87-9

The synthesis of 2-(4-nitrophenoxy)quinoxaline (3) is described. The reaction of (3) with hydroxide ion was studied in the presence and absence of micellar systems. Cationic micelles of cetyltrimethylammonium chloride and bromide (CTACl and CTABr) and tetradecyltrimethylammonium chloride and bromide (MTACl and MTABr) speed the reaction of (3) with hydroxide ion. The second-order rate constants at the micellar pseudophase are smaller than the second-order rate constant in water.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N563 | ChemSpider

New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Application of 108229-82-9, In a article, mentioned the application of 108229-82-9, Name is 6-Bromo-2,3-dichloroquinoxaline, molecular formula is C8H3BrCl2N2

A novel and facile synthesis of quinoxalinone derivatives was developed in which a wide range of 3-chloroquinoxalin-2(1H)-ones as key intermediates can be generated chemo- and regioselectively in good yields from corresponding quinoxaline-2,3(1H,4H)-diones. This new protocol is arguably superior, as it allows the design and preparation of a variety of bioactive quinoxaline-based compounds, which are particularly effective in the treatment of diabetes and its complications. Through this procedure, a new class of quinoxalinone-based aldose reductase inhibitors were synthesized successfully. Most of the inhibitors, with an N1-acetic acid head group and a substituted C3-phenoxy side chain, proved to be potent and selective. Their IC50 values ranged from 11.4 to 74.8nM. Among them, 2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid and 2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid were the most active. Structure-activity relationship and molecular docking studies highlighted the importance of the ether spacer in the C3-phenoxy side chains, and provided clear guidance on the contribution of substitutions both at the core structure and the side chain to activity.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2008 | ChemSpider

New Advances in Chemical Research, May 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. category: quinoxaline, We’ll be discussing some of the latest developments in chemical about CAS: 130345-50-5, name is Quinoxaline-6-carbaldehyde. In an article，Which mentioned a new discovery about 130345-50-5

The difluoromethyl group (CF2H) is of great interest in the area of medicinal chemistry. However, the investigation of molecular scaffolds containing this group has been hampered by the limitation of synthetic methods for the introduction of CF2H into heteroarenes. Herein we disclose a new strategy for the direct introduction of a difluoromethyl group into heteroarenes via the copper-mediated C-H oxidative difluoromethylation of heteroarenes with TMSCF2H. This mild and regioselective method enables the convenient synthesis of a range of difluoromethylated heteroarenes in high yields. The usage of 9,10-phenanthrenequinone (PQ) as an oxidant is critical to the success of this new difluoromethylation reaction.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N240 | ChemSpider

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. Related Products of 55687-33-7, In a article, mentioned the application of 55687-33-7, Name is 2-Chloro-6-fluoroquinoxaline, molecular formula is C8H4ClFN2

An aniline derivative represented by the formula (I): STR1 wherein A denotes CH or nitrogen atom; B denotes oxygen atom or sulfur atom; X1 and X2, independently of each other, denote hydrogen atom, halogen atom, trifluoromethyl group or nitro group; Y and Z, independently of each other, denote hydrogen atom or halogen atom, and a process for producing the same.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1083 | ChemSpider