New Advances in Chemical Research, May 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. category: quinoxaline, We’ll be discussing some of the latest developments in chemical about CAS: 130345-50-5, name is Quinoxaline-6-carbaldehyde. In an article，Which mentioned a new discovery about 130345-50-5
The difluoromethyl group (CF2H) is of great interest in the area of medicinal chemistry. However, the investigation of molecular scaffolds containing this group has been hampered by the limitation of synthetic methods for the introduction of CF2H into heteroarenes. Herein we disclose a new strategy for the direct introduction of a difluoromethyl group into heteroarenes via the copper-mediated C-H oxidative difluoromethylation of heteroarenes with TMSCF2H. This mild and regioselective method enables the convenient synthesis of a range of difluoromethylated heteroarenes in high yields. The usage of 9,10-phenanthrenequinone (PQ) as an oxidant is critical to the success of this new difluoromethylation reaction.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 130345-50-5
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N240 | ChemSpider