Synthetic Route of 2213-63-0, New research progress on 2213-63-0 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a article，once mentioned of 2213-63-0
Readily available octol 1, when treated with 3 mol of CH2ClBr, gave hexol 2 (3percent), tetrol 3 (7percent), diol 4 (17percent), and tetra-bridged 5 (10percent).The tetrol and diol served as starting materials for preparing mixed-bridged systems.Diol 4 reacted with 2,3-dichloroquinoxaline (7) to give 7percent of cavitand 8, whereas tetrol 3 reacted with only one of the 2 mol of quinoxaline 7 to give the chiral diol 9 (18percent).When 2 mol of diol 4 were treated with 1 mol of fluoranil (6), the mixture of 42percent of Z-shaped 10 (Z-10) and 12percent of C-shaped 10 (C-10) produced was easily separated.The crystal structures of 4*CHCl3*H2O, C-10*3CH3CN*CH2Cl2, Z-10*4CH3CO2CH2CH3, Z-10*4CH3COCH2CH3, and Z-10*6C6H5NO2 were determined and found to resemble what was predicted from molecular model examination.When 1 mol of diol 4 was mixed with tetrachlorotetraazaanthracene 12, a 16percent yield of what is probably Z-11 was obtained.One-to-one association constants of C-10 in CD2Cl2 at 21 deg C were determined by 1H NMR titrations with guests as follows: C6D5NO2 (Ka = 0.6 M-1), C6D5CD3 (Ka = 1.8 M-1), p-CD3C6D4CD3 (Ka = 1.6), and CH3COCH2CH3 (Ka = 1.2 M-1).Attempts to detect binding failed with 2-butyne, 2-pentyne, and methylcyclohexane, although molecular model examination suggested that all seven of the above guests are complementary to the highly preorganized ditopic cavity of C-10.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 2213-63-0, and how the biochemistry of the body works.Synthetic Route of 2213-63-0
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1297 | ChemSpider