Recommanded Product: 130345-50-5, New research progress on 130345-50-5 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.130345-50-5, Name is Quinoxaline-6-carbaldehyde, molecular formula is C9H6N2O. In a article，once mentioned of 130345-50-5
The transforming growth factor-beta (TGF-beta), in which overexpression has been associated with various diseases, has become an attractive molecular target for the treatment of cancers. Thirty-two quinoxaline-derivatives of 3-substituted-4-(quinoxalin-6-yl) pyrazoles 14a?d, 15a?d, 16a?d, 17a?d, 18a?d, 19a?d, 25a, 25b, 25d, 26a, 26b, 26d, 27b, and 27d were synthesized and evaluated for their activin TGF-beta type I receptor kinase and p38alpha mitogen activated protein (MAP) kinase inhibitory activity in enzymatic assays. Among these compounds, the most active compound 19b inhibited TGF-beta type I receptor kinase phosphorylation with an IC50 value of 0.28 muM, with 98% inhibition at 10 muM. Compound 19b also had good selectivity index of >35 against p38alpha MAP kinase, with 9.0-fold more selective than clinical candidate, compound 3 (LY-2157299). A molecular docking study was performed to identify the mechanism of action of the synthesized compounds and their good binding interactions were observed. ADMET prediction of good active compounds showed that these ones possess good pharmacokinetics and drug-likeness behavior.
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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N239 | ChemSpider