New Advances in Chemical Research, May 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing theoretical assessments of solvent structures and their interactions with reaction intermediates. category: quinoxaline, We’ll be discussing some of the latest developments in chemical about CAS: 18514-76-6, name is 5-Nitroquinoxaline. In an article，Which mentioned a new discovery about 18514-76-6
A series of thirty indole C-3 substituted 5-amino-6-(5-substituted-2- phenyl-1H-indol-1-yl)-4,5-dihydro-1,2,4-triazine-3(2H)-thione 5a-f, 6a-f, 7a-f, 8a-f and 9a-f were synthesized to explore prospective anticonvulsant agents. The derivative 1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-5- fluoro-2-phenyl-1H-indol-3-yl)ethanone (6b) had significant activity in maximal electroshock test with minimal duration of limb extension (5.40 ± 0.61 s) and quantitative median dose of 7 mg/kg. In subcutaneous pentylenetetrazole screen 1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-5-fluoro-2- phenyl-1H-indole-3-sulfonamide (7b) increased the seizure latency to onset of clonus and was effective at a median dose of 35 mg/kg. An in vitro radioligand binding assay on sodium channel and gamma-amino butyric acid estimation was also performed on active compounds to perceive the mechanistic procedure responsible for it action.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N827 | ChemSpider