New Advances in Chemical Research, May 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. Product Details of 6640-47-7, In a article, mentioned the application of 6640-47-7, Name is Quinoxaline-2,3-diamine, molecular formula is C8H8N4
A novel series of quinoxaline derivatives, as Multi-Target-Directed Ligands (MTDLs) for AD treatment, were designed by lending the core structural elements required for H3R antagonists and hybridizing BACE 1 inhibitor 1 with AChE inhibitor BYYT-25. A virtual database consisting of quinoxaline derivatives was first screened on a pharmacophore model of BACE 1 inhibitors, and then filtered by a molecular docking model of AChE. Seventeen quinoxaline derivatives with high score values were picked out, synthesized and evaluated for their biological activities. Compound 11a, the most effective MTDL, showed the potent activity to H3R/AChE/BACE 1 (H3R antagonism, IC50 = 280.0 ± 98.0 nM; H3R inverse agonism, IC50 = 189.3 ± 95.7 nM; AChE, IC50 = 483 ± 5 nM; BACE 1, 46.64 ± 2.55% inhibitory rate at 20 muM) and high selectivity over H1R/H2R/H4R. Furthermore, the protein binding patterns between 11a and AChE/BACE 1 showed that it makes several essential interactions with the enzymes.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Product Details of 6640-47-7, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6640-47-7
Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N258 | ChemSpider