Downstream synthetic route of 62163-09-1

The synthetic route of 62163-09-1 has been constantly updated, and we look forward to future research findings.

62163-09-1, 5-Chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,62163-09-1

EXAMPLE IV 5-(1-piperazinyl)quinoxalin, hydrochloride. 0.2 Mol (33.5 g) of 5-chloroquinoxalin and 2.1 mol (184 g) of piperazine were mixed in 180 ml of ethylene glycol and refluxed for 20 hours. The reaction mixture was poured on ice and acidified with concentrated hydrochloric acid and then extracted with 3*200 ml of ether. The water layer was made alkaline while cooling with ice, with 50% sodium hydroxide and then extracted with 3*600 ml of methylene chloride. The combined methylene chloride solution was washed successively with 1 l of 1N sodium hydroxide and a mixture of 925 ml of a saturated saline solution and 75 ml of 50% potassium hydroxide. The organic solution was dried on sodium sulphate and was then evaporated to dryness in vacuo. The residue was chromatographed over silica gel with a mixture of methylene chloride, methanol, and 25% ammonia (92:7.5:0.5) as eluent. The resulting free base was dissolved in ethanol and 1 equivalent of hydrochloric acid in ethanol was added. The title compound was obtained with a melting-point of 271-272 C.

The synthetic route of 62163-09-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duphar International Research B.V.; US5424313; (1995); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider