The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Hydroxyquinoline 1-oxide(SMILESS: OC1=CC=CC2=CC=C[N+]([O-])=C12,cas:1127-45-3) is researched.Recommanded Product: 16400-32-1. The article 《8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis》 in relation to this compound, is published in Drug Development Research. Let’s take a look at the latest research on this compound (cas:1127-45-3).
There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8-hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities. We conducted a structure-activity relationship study of the series regarding its antitubercular activity using 26 analogs. The 8-hydroxyquinolines showed good activity against M. tuberculosis, with min. inhibitory concentrations (MIC90) of <5μM for some analogs. Small substitutions at C5 resulted in the most potent activity. Substitutions at C2 generally decreased potency, although a sub-family of 2-styryl-substituted analogs retained activity. Representative compounds demonstrated bactericidal activity against replicating M. tuberculosis with >4 log kill at 10× MIC over 14 days. The majority of the compounds demonstrated cytotoxicity (IC50 of <100μM). Further development of this series as antitubercular agents should address the cytotoxicity liability. However, the 8-hydroxyquinoline series represents a useful tool for chem. genomics to identify novel targets in M. tuberculosis. From this literature《8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis》,we know some information about this compound(1127-45-3)Application In Synthesis of 8-Hydroxyquinoline 1-oxide, but this is not all information, there are many literatures related to this compound(1127-45-3).
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider