Application of 57825-30-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design. Author is Tian, Yulin; Jin, Jing; Wang, Xiaojian; Hu, Jinping; Xiao, Qiong; Zhou, Wanqi; Chen, Xiaoguang; Yin, Dali.
We have discovered a series of triazole/oxazole-containing 2-substituted 2-aminopropane-1,3-diol derivatives as potent and selective S1P1 agonists (prodrugs) based on pharmacophore-guided rational design. Most compounds showed high affinity and selectivity for S1P1 receptor. Compounds 19b, 19d and 19p displayed clear dose responsiveness in the lymphocyte reduction model when administered orally at doses of 0.3, 1.0, 3.0 mg/kg with reduced effect on heart rate. These three compounds were also identified to have favorable pharmacokinetic properties.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider