A new synthetic route of 57825-30-6

Here is just a brief introduction to this compound(57825-30-6)Synthetic Route of C9H11Br, more information about the compound(1-(Bromomethyl)-4-ethylbenzene) is in the article, you can click the link below.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 57825-30-6, is researched, Molecular C9H11Br, about 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists, the main research direction is quinazolinone preparation calcium sensing receptor antagonist SAR; osteoporosis PTH release quinazolinone preparation SAR.Synthetic Route of C9H11Br.

Parathyroid hormone (PTH) is an effective bone anabolic agent. However, only when administered by daily s.c. injections exposure of short duration is achieved, a prerequisite for an anabolic response. Instead of applying exogenous PTH, mobilization of endogenous stores of the hormone can be envisaged. The secretion of PTH stored in the parathyroid glands is mediated by a calcium sensing receptor (CaSR) a GPCR localized at the cell surface. Antagonists of CaSR (calcilytics) mimic a state of hypocalcemia and stimulate PTH release to the bloodstream. Screening of the internal compound collection for inhibition of CaSR signaling function afforded 2a (I). In vitro potency could be improved > 1000 fold by optimization of its chem. structure. The binding mode of our compounds was predicted based on mol. modeling and confirmed by testing with mutated receptors. While the compounds readily induced PTH release after iv application a special formulation was needed for oral activity. The required profile was achieved by using microemulsions. Excellent PK/PD correlation was found in rats and dogs. High levels of PTH were reached in plasma within minutes which reverted to baseline in about 1-2 h in both species.

Here is just a brief introduction to this compound(57825-30-6)Synthetic Route of C9H11Br, more information about the compound(1-(Bromomethyl)-4-ethylbenzene) is in the article, you can click the link below.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider