The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ) is researched.SDS of cas: 57825-30-6.Yamauchi, Satoshi; Nishimoto, Asuka; Nishiwaki, Hisashi; Nishi, Kosuke; Sugahara, Takuya published the article 《Discovery of stereospecific cytotoxicity of (8R,8’R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring》 about this compound( cas:57825-30-6 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: lignan arctigenin insect cells 28S rRNA structure activity relationship; 28S rRNA; Arctigenin; Insect cells; Lignan; Structure-activity relationship. Let’s learn more about this compound (cas:57825-30-6).
One of the arctigenin stereoisomers, (8R,8’R)-trans-form 1, showed stereospecific cytotoxicity against insect cells, Sf9 and NIAS-AeAl-2 cells. By the comparison with other stereoisomers, the most importance of the 8’R stereochem. for the higher activities was clarified. On the other hand, the wider range of activity level among stereoisomers against cancer cells, HL-60, was not observed The structure-activity relationship research using derivatives bearing (8R,8’R)-trans-form was performed to show the same level of activities of 3-iodo, 4-iodo, and 3,4-methylenedioxy derivatives 28, 29, and 36 as (8R,8’R)-trans-arctigenin 1. In the examination of thiono derivatives, 4-iodo thiono and 3,4-methylenedioxy thiono derivatives 66, 67 showed similar level of activities to that of (8R,8’R)-trans-arctigenin 1. The expression of ribosomal 28S rRNA gene of Sf9 cells was increased by (8R,8’R)-trans-arctigenin 1, whereas a degradation of DNA was not observed
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Quinoxaline – Wikipedia,
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