Ngamnithiporn, Aurapat; Jette, Carina I.; Bachman, Shoshana; Virgil, Scott C.; Stoltz, Brian M. published the article 《Nickel-catalyzed enantioselective allylic alkylation of lactones and lactams with unactivated allylic alcohols》. Keywords: alpha quaternary lactone enantioselective preparation; lactone allyl alc nickel catalyst allylic alkylation; enantioselective preparation alpha quaternary lactam; lactam allyl alc nickel catalyst allylic alkylation.They researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:221012-82-4) here.
The first nickel-catalyzed enantioselective allylic alkylation of lactone and lactam substrates to deliver α-quaternary lactones and lactams bearing an all-carbon quaternary stereocenter I [X = O, N-Bz, R1 = Me, Et; R2 = H, Ph, 2-furanyl, etc.] was reported. The reaction, which utilize a com. available chiral bisphosphine ligand, proceeded in good yield with a high level of enantioselectivity (up to 90% ee) on a range of unactivated allylic alcs. for both lactone and lactam nucleophiles. The utility of this method was further highlighted via a number of synthetically useful product transformations.
Here is just a brief introduction to this compound(221012-82-4)Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, more information about the compound((R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine) is in the article, you can click the link below.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider