Formula: C9H11Br. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists. Author is Widler, Leo; Altmann, Eva; Beerli, Rene; Breitenstein, Werner; Bouhelal, Rochdi; Buhl, Thomas; Gamse, Rainer; Gerspacher, Marc; Halleux, Christine; John, Markus R.; Lehmann, Hansjoerg; Kalb, Oskar; Kneissel, Michaela; Missbach, Martin; Muller, Irene R.; Reidemeister, Sibylle; Renaud, Johanne; Taillardat, Agnes; Tommasi, Ruben; Weiler, Sven; Wolf, Romain M.; Seuwen, Klaus.
Parathyroid hormone (PTH) is an effective bone anabolic agent. However, only when administered by daily s.c. injections exposure of short duration is achieved, a prerequisite for an anabolic response. Instead of applying exogenous PTH, mobilization of endogenous stores of the hormone can be envisaged. The secretion of PTH stored in the parathyroid glands is mediated by a calcium sensing receptor (CaSR) a GPCR localized at the cell surface. Antagonists of CaSR (calcilytics) mimic a state of hypocalcemia and stimulate PTH release to the bloodstream. Screening of the internal compound collection for inhibition of CaSR signaling function afforded 2a (I). In vitro potency could be improved > 1000 fold by optimization of its chem. structure. The binding mode of our compounds was predicted based on mol. modeling and confirmed by testing with mutated receptors. While the compounds readily induced PTH release after iv application a special formulation was needed for oral activity. The required profile was achieved by using microemulsions. Excellent PK/PD correlation was found in rats and dogs. High levels of PTH were reached in plasma within minutes which reverted to baseline in about 1-2 h in both species.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider