The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ) is researched.Quality Control of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.Suzuki, Shunsuke; Shibata, Yu; Tanaka, Ken published the article 《Rhodium-Catalyzed Asymmetric [2+2+2] Cycloaddition of 1,6-Enynes with Racemic Secondary Allylic Alcohols through Kinetic Resolution》 about this compound( cas:221012-82-4 ) in Chemistry – A European Journal. Keywords: bicyclic cyclohexene preparation enantioselective diastereoselective; enyne allylic alc cycloaddition reaction rhodium catalyst; allylic alcohols; asymmetric [2+2+2] cycloaddition; enynes; kinetic resolution; rhodium. Let’s learn more about this compound (cas:221012-82-4).
It has been established that a cationic rhodium(I)/P-phos complex catalyzes the asym. [2+2+2] cycloaddition of 1,6-enynes R1CCCH2ZCH2CH(=CH2)R2 (R1 = Me, Ph, pentyl; R2 = H, Me) with racemic secondary allylic alcs. R3CH(OH)CH=CH2 to produce the corresponding chiral bicyclic cyclohexenes I, possessing three stereogenic centers, as a single diastereomer with excellent ee values. Mechanistic experiments revealed that the present cycloaddition proceeds through the kinetic resolution of the racemic secondary allylic alcs., in which one enantiomer preferentially reacts with the 1,6-enyne.
In some applications, this compound(221012-82-4)Quality Control of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider