Category: quinoxaline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Modified amino acids and peptides. Part 2. A convenient conversion of amino and peptide alcohols into amines.
A convenient general method for the conversion of N-protected amino and peptide alcs. RNHCHR1CH2R2 (I; R = Z, Boc, Z-Ala, R1 = H, PhCH2, Me, CH2CHMe2, R2 = OH; Z = PhCH2O2C, Boc = Me3CO2C) into amines I (R2 = NH2, NEt2) is described. Thus, treatment of I (R = OH) with MeSO2Cl gave the corresponding mesylates, which underwent substitution with HNEt2 to give I (R2 = NEt2) or NaN3 to give the corresponding azides I (R2 = N3). Hydrogenation of I (R2 = N3) gave the corresponding monoprotected diamines I (R = Boc, R2 = NH2) or free diamines I (R = H, R2 = NH2), depending on the protecting group. Selective reduction of the azido group in I (R = Z, R2 = N3) was performed in high yield using NaBH4 in the presence of 10% Pd/C to give I (R = Z, R2 = NH2).
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider