Ikeda, Masazumi; Maruyama, Kazumi; Nobuhara, Youichi; Yamada, Toshihiro; Okabe, Susumu published the article 《Synthesis and cytoprotective antiulcer activity of 2- or 4-(1H-pyrazol-1-yl)pyrimidine derivatives related to mepirizole and dulcerozine》. Keywords: pyrimidine pyrazolyl imidazolyl triazolyl antiulcer cytoprotective; mepirizole derivative preparation antiulcer cytoprotective; dulcerozine derivative preparation antiulcer cytoprotective.They researched the compound: 4-Chloro-6-(1H-imidazol-1-yl)pyrimidine( cas:114834-02-5 ).COA of Formula: C7H5ClN4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:114834-02-5) here.
A variety of (1H-pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1,2,4,-triazol-1-yl)pyrimidines were prepared and evaluated for cytoprotective antiulcer activity. The compounds include members of structures I [R = pyrazol-1-yl, 3-methylpyrazol-1-yl, imidazol-1-yl, 1,2,4-triazol-1-yl; R1 = H, OMe, OEt; R2 = H, Me] and II [R = pyrazol-1-yl, imidazol-1-yl; R1 = OMe, OEt, OPh, NH2, NHMe, pyrrolidino, piperidino, H, SMe, etc.]. Among them, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)pyrimidine (III) showed potent inhibition of HCl-EtOH-induced and water-immersion stress-induced ulcers in rats, as well as low acute toxicity.
There is still a lot of research devoted to this compound(SMILES：ClC1=NC=NC(N2C=CN=C2)=C1)COA of Formula: C7H5ClN4, and with the development of science, more effects of this compound(114834-02-5) can be discovered.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider