Introduction of a new synthetic route about 221012-82-4

There is still a lot of research devoted to this compound(SMILES：COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6)SDS of cas: 221012-82-4, and with the development of science, more effects of this compound(221012-82-4) can be discovered.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Maj, Anna M.; Suisse, Isabelle; Hardouin, Christophe; Agbossou-Niedercorn, Francine researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).SDS of cas: 221012-82-4.They published the article 《Synthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines》 about this compound( cas:221012-82-4 ) in Tetrahedron. Keywords: quinoline cyclooctadiene iridium chloride chiral bisphosphine ligand iodine hydrogenation; tetrahydroquinoline stereoselective preparation. We’ll tell you more about this compound (cas:221012-82-4).

The asym. hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir(cod)Cl]2, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee.

There is still a lot of research devoted to this compound(SMILES：COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6)SDS of cas: 221012-82-4, and with the development of science, more effects of this compound(221012-82-4) can be discovered.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider