So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhou, Bingcheng; Li, Xun; Li, Yan; Xu, Yaochun; Zhang, Zhengxi; Zhou, Mi; Zhang, Xinglong; Liu, Zhen; Zhou, Jiahai; Cao, Chunyang; Yu, Biao; Wang, Renxiao researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene.They published the article 《Discovery and Development of Thiazolo[3,2-a]pyrimidinone Derivatives as General Inhibitors of Bcl-2 Family Proteins》 about this compound( cas:57825-30-6 ) in ChemMedChem. Keywords: thiazolo pyrimidinone preparation Bcl2 protein inhibitor SAR. We’ll tell you more about this compound (cas:57825-30-6).
A class of compounds with a common thiazolo[3,2-a]pyrimidinone motif has been developed as general inhibitors of Bcl-2 family proteins. The lead compound was originally identified in a random screening of a small compound library using a fluorescence polarization-based competitive binding assay. Its binding to the Bcl-xL protein was further confirmed by 15N-HSQC NMR experiments Structural modifications on the lead compound were guided by the outcomes of mol. modeling studies. Among the 42 compounds obtained, a number of them exhibited much improved binding affinities to Bcl-2 family proteins as compared to the lead compound The most potent compound, BCL-LZH-40 (I), inhibited the binding of BH3 peptides to Bcl-xL, Bcl-2, and Mcl-1 with inhibition constants (Ki) of 17, 534, and 200 nM, resp.
There is still a lot of research devoted to this compound(SMILES:CCC1=CC=C(CBr)C=C1)Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene, and with the development of science, more effects of this compound(57825-30-6) can be discovered.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider