Day: April 6, 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Effects of substituents on the intramolecular hydrogen bond in 8-quinolinol-N-oxides, published in 1980-10-31, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, SDS of cas: 1127-45-3.

IR spectral and deuteration studies on 8-quinolinol-N-oxides and its 5-nitro-, 5-nitroso-, 5-amino-, 5-phenylazo-, 5,7-dibromo- and 5,7-diiodo-derivatives in solid and in solution state confirm the presence of a strong intramol. unsym. H bond involving the hydroxyl hydrogen atom and the N-oxide oxygen atom. The structure of the complex absorption pattern in the region 2850 cm-1-1800 cm-1 is explained in terms of Fermi resonance interaction between the νOH of O-H…O and the overtone and combination bands of (δOH + νC-O) and other fundamental vibrations of the mol. The absence of any significant absorptions in the νOH region in the spectra of 5,7-dichloro- and 5,7-dinitro-derivatives coupled with strong and broad absorption in 1500 cm-1-600 cm-1 region is perhaps due to the presence of very short hydrogen bonds in these compounds

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Oh, Sangmi; Kim, Sungbum; Kong, Sunju; Yang, Gyongseon; Lee, Nakyung; Han, Dawoon; Goo, Junghyun; Siqueira-Neto, Jair L.; Freitas-Junior, Lucio H.; Song, Rita published the article 《Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi》. Keywords: dihydroimidazobenzimidazole derivative preparation antileishmanial antitrypanosomal; 2,3-Dihydroimidazo[1,2-a]benzimidazole; Anti-parasitic activity; Chagas disease; Leishmaniasis.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Electric Literature of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A high-throughput (HTS) and high-content screening (HCS) campaign of a com. library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogs as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which were known as the causative parasites for visceral leishmaniasis and Chagas disease, resp. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds I and II showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, resp.) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 μM, resp.) without serious cytotoxicity toward THP-1 and U2OS cell lines.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Qiao; Wang, Simin; Zhang, Qian; Xiong, Tao published the article 《Radical Addition-Triggered Remote Migratory Isomerization of Unactivated Alkenes to Difluoromethylene-Containing Alkenes Enabled by Bimetallic Catalysis》. Keywords: difluoromethyl alkene preparation diastereoselective; alkene radical addition isomerization.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Quality Control of 1-(Bromomethyl)-4-ethylbenzene. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A fascinating alkene remote migratory isomerization engendered by carbon radical addition to C=C bond in alkenes Ar(CH2)nCH=CH2 (Ar = C6H5, 4-FC6H4, 2-pyridyl, etc.; n = 2, 4, 5, 6, 7) via bimetallic catalysis has been disclosed. A diverse array of alkenes bearing distantly incorporated the difluoromethylene ArCH=CH(CH2)mCF2C(O)R (m = 1, 4, 5, 6, 9; R = OMe, OEt, morpholin-4-yl, etc.) functionality have been expediently obtained. The retainment of C=C bonds in products could serve as an useful synthetic platform furnishing otherwise difficult to access value-added densely functionalized difluoromethylene containing mols. In addition, some exptl. studies have been implemented to shed light on the probable mechanism.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 221012-82-4, is researched, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2Journal, Advanced Synthesis & Catalysis called Copper-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Dienes, Author is He, Cheng-Yu; Li, Qing-Hua; Wang, Xin; Wang, Feng; Tian, Ping; Lin, Guo-Qiang, the main research direction is copper catalyzed asym borylative cyclization cyclohexadienone diene; borylated tetrahydrobenzofuranone preparation; crystal structure borylated tetrahydrobenzofuranone; mol structure borylated tetrahydrobenzofuranone.Category: quinoxaline.

Due to the low reactivity of 1,6-dienes and the challenge of selectively differentiating such two olefins, the development of metal-catalyzed asym. cyclization of 1,6-dienes remains largely underdeveloped. Herein, the authors describe the 1st Cu(I)-catalyzed asym. borylative cyclization of cyclohexadienone-tethered terminal alkenes (1,6-dienes) via a tandem process: the regioselective borocupration of the electron-rich terminal alkene and subsequent conjugate addition of stereospecific secondary alkyl-Cu(I) to the electron-deficient cyclohexadienone, affording enantioenriched bicyclic skeletons bearing three contiguous stereocenters in all cis-form. Meanwhile, this mild catalytic protocol is generally compatible with a wide range of functional groups, which allows further facile conversion of the cyclization products.

There is still a lot of research devoted to this compound(SMILES：COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6)Category: quinoxaline, and with the development of science, more effects of this compound(221012-82-4) can be discovered.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Chloro(1,5-cyclooctadiene)copper(I) dimer( cas:32717-95-6 ) is researched.Electric Literature of C16H16Cl2Cu2.Meyer, Lueder U.; de Meijere, Armin published the article 《Gold catalyzed rearrangements of strained small ring hydrocarbons》 about this compound( cas:32717-95-6 ) in Tetrahedron Letters. Keywords: polycycloalkane gold catalysis rearrangement; small ring hydrocarbon rearrangement. Let’s learn more about this compound (cas:32717-95-6).

Diademane (I) underwent Au-catalyzed rearrangement to give 50% snoutene (II) together with 5% of the thermally rearranged product, triquinacene. At elevated temperatures, II underwent Au-catalyzed rearrangement to basketene (III), which subsequently thermally rearranged to Nenitzescu’s hydrocarbon. Similar catalysis of the diene IV, gave >90% tetrahydronaphthalene.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Chai, Xiaoyun; Zhang, Jun; Yu, Shichong; Hu, Honggang; Zou, Yan; Zhao, Qingjie; Dan, Zhigang; Zhang, Dazhi; Wu, Qiuye published the article 《Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols》. Keywords: triazolyl difluorophenyl aralkylamino propanol preparation antifungal activity computational chem.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Computed Properties of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, e.g., I, as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Liu, Yong-Hai; Li, Da-Li; Li, Qin-Hua; Yang, Jun-Fang; Lu, Lu-De published an article about the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1 ).Formula: C9H11Br. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:57825-30-6) through the article.

A novel and convenient approach for the preparation of [3R-(3α,4β,5α,6β)]-2-[7-chloro-1-(4-ethylbenzyl)-5-methyl-1H-indol-3-yl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol starting from 7-chloro-5-methylindole by three steps was developed. The product was achieved in 72% yield.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-ethylbenzene(SMILESS: CCC1=CC=C(CBr)C=C1,cas:57825-30-6) is researched.Category: indazoles. The article 《A convergent formal [4+2] cycloaddition of 1,6-diynes and benzyl azides: construction of spiro-polyheterocycles》 in relation to this compound, is published in Organic & Biomolecular Chemistry. Let’s take a look at the latest research on this compound (cas:57825-30-6).

A convergent formal [4+2] cycloaddition reaction for the construction of structurally appealing spiro-tetrahydroquinolines has been developed, in which, a one-pot reaction is established for the in situ generation of two reagents, a cyclic alkyne and an N-aryliminium ion, from the corresponding precursors in the presence of an Au-catalyst and Bronsted acid, resp.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 19777-66-3, is researched, Molecular C3H12Cl2N2, about Synthesis of dexrazoxane, the main research direction is dexrazoxane synthesis diaminopropane.Application of 19777-66-3.

Dexrazoxane, a cardiac medicine, was synthesized in 35.7% overall yield starting from racemic 1,2-diaminopropane. The resolution of l,2-diaminopropane with D-(-)-tartaric acid followed by reaction with potassium chloride resulted in (S)-1,2-diaminopropane dihydrochloride, which was further converted into the title compound in two steps. The structure was confirmed with 1H NMR and IR.

There is still a lot of research devoted to this compound(SMILES：C[C@H](N)CN.[H]Cl.[H]Cl)Application of 19777-66-3, and with the development of science, more effects of this compound(19777-66-3) can be discovered.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 19777-66-3, is researched, Molecular C3H12Cl2N2, about Synthesis of a water-soluble chiral NMR shift reagent: (S)-PDTA, the main research direction is alanine transformation chirality retention; PDTA water soluble chiral NMR shift reagent stereoselective preparation; propylenediamine tetraacetic acid stereoselective preparation.Reference of (S)-Propane-1,2-diamine dihydrochloride.

A five-step synthesis of the water-soluble chiral polydentate ligand, (S)-PDTA (I) starting from L-alanine has been worked out, via 5 steps with retention of chirality. The total yield is 50.7% (average of ∼88% for each step), while published methods report 33.4% total yield over four steps.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider