Research on new synthetic routes about 1127-45-3

There is still a lot of research devoted to this compound(SMILES:OC1=CC=CC2=CC=C[N+]([O-])=C12)Reference of 8-Hydroxyquinoline 1-oxide, and with the development of science, more effects of this compound(1127-45-3) can be discovered.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called 8-Hydroxy-1-methoxyquinoline methosulfate, published in 1965, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, Reference of 8-Hydroxyquinoline 1-oxide.

The crude title compound, not described previously, m. 126-8° (decomposition) and is very soluble in water, soluble in alcs., and insoluble in nonpolar solvents. Reaction with nucleophilic compounds gives 2-substituted 8-hydroxyquinolines. A mixture of 48.3 g. powd. 8-hydroxyquinoline 1-oxide (m. 138.5-39°) (Phillips, et al., CA 51, 11349a; Murase and Demura, CA 58 3390b, recrystallized twice from water and C6H6) and 37.9 g. freshly distilled Me2SO4 is warmed on a water bath 2 hrs. with reflux. The mass is cooled and stirred until crystallization, 200 ml. dry Et2O is added, and the mixture stirred until all material is hardened. The solid is washed with 50-100 ml. Et2O in a mortar after filtration, washed on the filter with Et2O, and dried in a vacuum desiccator. Yield 77.6-9.3 g. hygroscopic material. Recrystallization of 20 g. from EtOH-Et2O gave 3.67 g., m. 143-4.5°.

There is still a lot of research devoted to this compound(SMILES:OC1=CC=CC2=CC=C[N+]([O-])=C12)Reference of 8-Hydroxyquinoline 1-oxide, and with the development of science, more effects of this compound(1127-45-3) can be discovered.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider