Oh, Sangmi; Kim, Sungbum; Kong, Sunju; Yang, Gyongseon; Lee, Nakyung; Han, Dawoon; Goo, Junghyun; Siqueira-Neto, Jair L.; Freitas-Junior, Lucio H.; Song, Rita published the article 《Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi》. Keywords: dihydroimidazobenzimidazole derivative preparation antileishmanial antitrypanosomal; 2,3-Dihydroimidazo[1,2-a]benzimidazole; Anti-parasitic activity; Chagas disease; Leishmaniasis.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Electric Literature of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.
A high-throughput (HTS) and high-content screening (HCS) campaign of a com. library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogs as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which were known as the causative parasites for visceral leishmaniasis and Chagas disease, resp. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds I and II showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, resp.) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 μM, resp.) without serious cytotoxicity toward THP-1 and U2OS cell lines.
There is still a lot of research devoted to this compound(SMILES：CCC1=CC=C(CBr)C=C1)Electric Literature of C9H11Br, and with the development of science, more effects of this compound(57825-30-6) can be discovered.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider