Holvey, Rhian S.; Valkov, Eugene; Neal, David; Stewart, Murray; Abell, Chris published an article about the compound: (4-(Pyridin-4-yl)phenyl)methanol( cas:217192-22-8,SMILESS:OCC1=CC=C(C2=CC=NC=C2)C=C1 ).SDS of cas: 217192-22-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:217192-22-8) through the article.
Protein-protein interactions are difficult therapeutic targets, and inhibiting pathol. relevant interactions without disrupting other essential ones presents an addnl. challenge. Herein the authors report how this might be achieved for the potential anticancer target, the TPX2-importin-α interaction. Importin-α is a nuclear transport protein that regulates the spindle assembly protein TPX2. It has two binding sites-major and minor-to which partners bind. Most nuclear transport cargoes use the major site, whereas TPX2 binds principally to the minor site. Fragment-based approaches were used to identify small mols. that bind importin-α, and crystallog. studies identified a lead series that was observed to bind specifically to the minor site, representing the first ligands specific for this site. Structure-guided synthesis informed the elaboration of these fragments to explore the source of ligand selectivity between the minor and major sites. These ligands are starting points for the development of inhibitors of this protein-protein interaction.
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Quinoxaline – Wikipedia,
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