SDS of cas: 57825-30-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Design, synthesis and activity evaluation of 9-substituted-2-amino-6-guanidinopurines as acrosin inhibitors. Author is Zhang, Xiao-Meng; Zhu, Ju; Liu, Xue-Fei; Sheng, Chun-Quan; Zheng, Can-Hui; Fu, Xiao-Dan; Song, Yun-Long; Zhou, You-Jun; Lu, Jia-Guo.
Acrosin, a trypsin-like endoprotease, present in the acrosome of spermatozoa, is a promising target for contraceptive agents. Based on the previous homol. modeling and the anal. of the properties of the activity site of human acrosin, a series of 9-substituted-2-amino-6-guanidinopurines were designed and synthesized on a scaffold represented by KF950. The structures of all the title compounds were confined by 1H NMR, MS, IR and elemental anal. Intermediate 5m was determined by single crystal X-ray diffraction anal. The inhibitory activities against acrosin of all target compounds were tested in vitro and all of them exhibited much more inhibitory activities against acrosin, resp., with pos. control, TLCK. Compound 6z exhibited similar inhibitory activities against KF950.
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Reference:
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Quinoxaline | C8H6N2 | ChemSpider