So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Holvey, Rhian S.; Valkov, Eugene; Neal, David; Stewart, Murray; Abell, Chris researched the compound: (4-(Pyridin-4-yl)phenyl)methanol( cas:217192-22-8 ).Safety of (4-(Pyridin-4-yl)phenyl)methanol.They published the article 《Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design》 about this compound( cas:217192-22-8 ) in ChemMedChem. Keywords: TPX importin protein interaction inhibitor; crystal structure; cancer; fragment-based ligand design; nuclear transporters; protein-protein interactions; structure-guided ligand design. We’ll tell you more about this compound (cas:217192-22-8).
Protein-protein interactions are difficult therapeutic targets, and inhibiting pathol. relevant interactions without disrupting other essential ones presents an addnl. challenge. Herein the authors report how this might be achieved for the potential anticancer target, the TPX2-importin-α interaction. Importin-α is a nuclear transport protein that regulates the spindle assembly protein TPX2. It has two binding sites-major and minor-to which partners bind. Most nuclear transport cargoes use the major site, whereas TPX2 binds principally to the minor site. Fragment-based approaches were used to identify small mols. that bind importin-α, and crystallog. studies identified a lead series that was observed to bind specifically to the minor site, representing the first ligands specific for this site. Structure-guided synthesis informed the elaboration of these fragments to explore the source of ligand selectivity between the minor and major sites. These ligands are starting points for the development of inhibitors of this protein-protein interaction.
If you want to learn more about this compound((4-(Pyridin-4-yl)phenyl)methanol)Safety of (4-(Pyridin-4-yl)phenyl)methanol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(217192-22-8).
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider